硫酸吲哚钾盐|T4938|TargetMol

Potassium 1H-indol-3-yl sulfate
2642-37-7

￥169 1mg 起订

￥357 5mg 起订

￥511 10mg 起订

上海更新日期：2024-09-29

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产品详情:

中文名称：: 硫酸吲哚钾盐

英文名称：: Potassium 1H-indol-3-yl sulfate

CAS号：: 2642-37-7

品牌：: TargetMol

产地：: 美国

保存条件：: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 3 months | Shipping with blue ice.

纯度规格：: 99.71%

产品类别：: 抑制剂

货号：: T4938

Product Introduction

Bioactivity

Name	Potassium 1H-indol-3-yl sulfate
Description	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of immune-inflammatory conditions and potassium 1H-indol-3-yl sulfate has been shown to be a ligand for AhR. Potassium 1H-indol-3-yl sulfate is also a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole, which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver, which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised, potassium 1H-indol-3-yl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease. Potassium 1H-indol-3-yl sulfate at 250 μM can induce the activation of NF-Κb, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity.
Storage	store at low temperature \| Pure form: -20°C for 3 years \| In solvent: -80°C for 3 months \| Shipping with blue ice.
Solubility Information	DMSO : 100 mg/mL (397.93 mM), Sonication is recommended. H2O : 50 mg/mL (198.97 mM), Sonication is recommended.
Keywords	Potassium 1H-indol-3-yl Sulfate \| Potassium 1Hindol3yl sulfate \| Inhibitor \| Indoxyl sulfate potassium \| Endogenous Metabolite \| Potassium 3-indoxyl Sulfate \| inhibit \| Potassium 1H indol 3 yl sulfate
Inhibitors Related	Formamide \| Guanidine hydrochloride \| Naringin \| Oleic acid \| Daidzein \| Vanillin \| Glycerol \| Sucrose \| Ferulic Acid \| 3-Indoleacetic acid \| Thymidine \| Fumaric acid
Related Compound Libraries	Bioactive Compound Library \| Human Endogenous Metabolite Compound Library Plus \| Bioactive Compounds Library Max \| Human Endogenous Metabolite Library \| Gut Microbial Metabolite Library \| NO PAINS Compound Library \| Natural Product Library \| Natural Product Library for HTS \| Target-Focused Phenotypic Screening Library \| Human Metabolite Library

硫酸吲哚钾盐|||Potassium 3-indoxyl sulfate|||Indoxyl sulfate potassium salt|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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