2642-37-7Indoxyl Sulfate (potassium salt)

产品属性：

Cas No.2642-37-7

别名 N/A

化学名 3-(hydrogen sulfate), 1H-indol-3-ol, monopotassium salt

分子式 C8H6NO4S ? K

分子量 251.3

溶解度 30mg/mL in DMSO or DMF

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Indoxyl sulfate is a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole, which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver, which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised, indoxyl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease. [1]  Indoxyl sulfate at 250 &#181M can induce the activation of NF-κB, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity.[2]

Reference:

[1]. Niwa, T. Uremic toxicity of indoxyl sulfate. Nagoya J.Med.Sci. 72(1-2), 1-11 (2010).

[2]. Shimizu, H., Yisireyili, M., Nishijima, F., et al. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am.J.Nephrol. 37(2), 97-103 (2013).