化合物 Belotecan hydrochloride|T7551|TargetMol

Belotecan hydrochloride
213819-48-8

￥413 1mg 起订

￥980 5mg 起订

￥1490 10mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 Belotecan hydrochloride

英文名称：: Belotecan hydrochloride

CAS号：: 213819-48-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: ≥95%

产品类别：: 抑制剂

货号：: T7551

Product Introduction

Bioactivity

Name	Belotecan hydrochloride
Description	Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
Cell Research	Cells at a density of 2×10^4 cells/well in 100 μl RPMI with 10% FBS were added to the wells of a 96-well plate.?The cells were treated with different concentrations (0.01, 0.1, 0.5, 1, 5 and 10 μg/ml) of CKD-602 for 24, 48 and 72 h. Control samples of each cell line were treated with medium only.?For the viability assay, 20 μl/well CellTiter 96AQueous One Solution Reagent (MTS) was added.?After 1 h incubation at 37°C in a humidified atmosphere of 5% CO2, the absorbance at 490 nm was recorded using an ELISA plate reader ?The assay was performed in triplicate with three independent experiments for each condition.?The data from the treatment groups were normalized to those of the control samples and are presented as the mean ±standard error of the mean.?The half maximal (50%) inhibitory concentration (IC50) values were calculated from the dose-response curve[1].
In vitro	Belotecan hydrochloride(CKD-602) 在所有细胞系中的效果显示出显著的时间和剂量依赖性细胞毒作用。在治疗72小时后，YD-8、YD-9和YD-38细胞的细胞活性IC50值分别为2.4 μg/ml、0.18 μg/ml和0.05 μg/ml[1]。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 10 mg/mL (21.28 mM), Sonication is recommended.
Keywords	Belotecan \| Topoisomerase \| Inhibitor \| Belotecan hydrochloride \| CKD602 \| Belotecan Hydrochloride \| CKD 602 \| inhibit
Inhibitors Related	Prulifloxacin \| Norfloxacin \| Ciprofloxacin \| Irinotecan hydrochloride trihydrate \| Berberine chloride \| Etoposide \| Ciprofloxacin monohydrochloride \| EIDD-1931 \| Pefloxacin Mesylate \| Camptothecin \| Flumequine \| Enoxacin
Related Compound Libraries	Inhibitor Library \| Anti-Cancer Active Compound Library \| Anti-Cancer Approved Drug Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| FDA-Approved & Pharmacopeia Drug Library \| Anti-Aging Compound Library \| Drug Repurposing Compound Library \| Anti-Cancer Clinical Compound Library \| Anti-Cancer Drug Library

CKD-602|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务