丙二酸二甲酯|T5695|TargetMol

Dimethyl malonate
108-59-8

￥196 100mg 起订

￥418 500mg 起订

上海更新日期：2024-09-24

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 丙二酸二甲酯

英文名称：: Dimethyl malonate

CAS号：: 108-59-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: ≥95%

产品类别：: 抑制剂

货号：: T5695

Product Introduction

Bioactivity

Name	Dimethyl malonate
Description	Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.
Animal Research	Rats were subjected to a 6?min of CA, and cardiopulmonary resuscitation (CPR) was performed with administration of normal saline or dimethyl malonate (DMM, a competitive inhibitor of SDH). After the return of spontaneous circulation, neurological function of the rats was assessed by a tape removal test for 3?days. The rats were then sacrificed, and their brains were used to assess neuronal apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Hippocampal tissues were used for Western blotting analysis and biochemical detection. In addition, hippocampal mitochondria during CA and CPR were isolated. The relative mitochondrial membrane potential (MMP) and cytochrome C in the cytosol were detected.
In vivo	Dimethyl malonate抑制琥珀酸脱氢酶，减轻心脏骤停大鼠模型中的脑损伤。Dimethyl malonate抑制caspase-3的激活，增强HIF-1α的表达。此外，Dimethyl malonate抑制了CPR后过度的MMP超极化，并阻止了细胞色素C的释放。因此，通过Dimethyl malonate抑制SDH减轻了CA后的脑损伤，主要机制包括抑制MMP的过度超极化，减少mtROS的生成，并稳定HIF-1α的结构。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : 100 mg/ml (756.945 mM) DMSO : 100 mg/ml (756.945 mM)
Keywords	Dimethyl Malonate \| Dimethyl malonate
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Flavor Compound Library \| NO PAINS Compound Library \| Natural Product Library \| Natural Product Library for HTS \| Human Metabolite Library

丙二酸二甲酯|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子