二甲基姜黄素|TQ0214|TargetMol

Dimethylcurcumin
52328-98-0

￥760 20mg 起订

上海更新日期：2024-09-24

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 二甲基姜黄素

英文名称：: Dimethylcurcumin

CAS号：: 52328-98-0

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.96%

产品类别：: 抑制剂

货号：: TQ0214

Product Introduction

Bioactivity

Name	Dimethylcurcumin
Description	Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.
Cell Research	For the cell survival assay, the PC12/AR-112Q and PC12/AR-10Q cells are cultured as described previously and incubated cells in the presence of 10 μg/mL doxycycline for 24 h. Then the cells are treated with a vehicle, 5 μM Dimethylcurcumin or 10 μM Dimethylcurcumin, along with 1 nM DHT, and determined cell viability using Trypan blue staining at specific time intervals [2].
Animal Research	CWR22Rv1 cells (1×10^6 cells per site) are injected into both anterior prostates of the castrated nude mice after 2 weeks of implantation. The mice were randomly divided into two groups (four mice/eight tumors each group) and either receive 75 mg/kg Dimethylcurcumin intraperitoneal injection or vehicle control every other day. After 4 weeks of treatment, all mice are killed to examine the tumor growth. Body weights and mice activity are measured weekly [1].
In vitro	Dimethylcurcumin 在不同的人类前列腺癌细胞中以剂量依赖的方式降解 fAR 和 AR3。在 CWR22Rv1-fARKD 细胞中，Dimethylcurcumin 也能有效地抑制 AR 靶基因。Dimethylcurcumin (5 或 10 μM) 显著抑制三种前列腺癌细胞线中 DHT 诱导的细胞增长。Dimethylcurcumin 通过降解 C81 和 C4-2 细胞中的 fAR 和异位 AR3 来抑制 AR 靶基因和细胞生长 [1]。ASC-J9 减少细胞中 AR 聚集的 AR-112Q。Dimethylcurcumin 抑制 SBMA PC12/AR-112Q 细胞中的 AR-112Q 聚集 [2]。
In vivo	Dimethylcurcumin（75 mg/kg，腹腔注射）能在体内降解异种移植肿瘤中的fAR和AR3，并且经ASC-J9处理的肿瘤显示Ki67阳性细胞显著减少[1]。Dimethylcurcumin（50 mg/kg，每48小时一次，腹腔注射）显著改善了AR-97Q小鼠的脊髓性肌萎缩症状，并改善了神经肌肉病理学发现[2]。与接受经典ADT/去势治疗且血清雄激素水平较低的小鼠相比，ASC-J9处理的小鼠展示了显著更小的前列腺肿瘤体积[3]。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 48 mg/mL (121.08 mM) H2O : Insoluble
Keywords	Dimethylcurcumin \| inhibit \| Androgen Receptor \| GO-Y 025 \| Inhibitor \| GO-Y-025
Inhibitors Related	DHEA \| Bavdegalutamide \| Ostarine \| 2-hydroxy Flutamide \| S-23 \| Flutamide \| Sunset Yellow FCF \| Bicalutamide \| Allura Red AC \| Dehydroisoandrosterone 3-acetate \| Adrenosterone \| Octinoxate
Related Compound Libraries	Bioactive Compound Library \| Anti-Cancer Active Compound Library \| Food as Medicine Compound Library \| Traditional Chinese Medicine Monomer Library \| Drug Repurposing Compound Library \| Natural Product Library for HTS \| Anti-Cancer Clinical Compound Library \| Anti-Cancer Drug Library

二甲基姜黄素|||GO-Y025|||ASC-J9|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子