52328-98-0
基本信息
二甲基姜黄素
ASC-J9 生产厂家
二甲基姜黄素, ≥95%
Dimethylcurcumin
Dimethylcurcumin, ≥95%
(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one
1,4,6-Heptatrien-3-one, 1,7-bis(3,4-diMethoxyphenyl)-5-hydroxy-,(1E,4Z,6E)-
(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one (ASC-J9)
Dimethylcurcumin【(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one】
物理化学性质
| 外观性状 | 可溶于甲醇、乙醇、DMSO等有机溶剂。 |
| 熔点 | 129-130℃ |
| 沸点 | 588.6±50.0 °C(Predicted) |
| 密度 | 1.191 |
| 储存条件 | -20°C储存 |
| 溶解度 | insoluble in EtOH; insoluble in H2O; ≥16.65 mg/mL in DMSO |
| 酸度系数(pKa) | 8.34±0.60(Predicted) |
| 形态 | 固体 |
| 颜色 | Light yellow to red |
| InChI | InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15- |
| InChIKey | ZMGUKFHHNQMKJI-CIOHCNBKSA-N |
| SMILES | C(/C1=CC=C(OC)C(OC)=C1)=C\C(=O)/C=C(\O)/C=C/C1=CC=C(OC)C(OC)=C1 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
二甲基姜黄素价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/09/19 | S6630 | 二甲基姜黄素 Dimethylcurcumin (ASC-J9) | 52328-98-0 | 5mg | 1670.91元 |
| 2025/09/19 | S6630 | 二甲基姜黄素 Dimethylcurcumin (ASC-J9) | 52328-98-0 | 25mg | 5170.9元 |
| 2025/05/22 | HY-15194 | 二甲基姜黄素 Dimethylcurcumin | 52328-98-0 | 5mg | 365元 |
常见问题列表
| Target | Value |
|
AR
() |
Dimethylcurcumin (ASC-J9) is able to degrade fAR and AR3 in a dose-dependent manner in various human PCa cells. Dimethylcurcumin (ASC-J9) can also effectively suppress AR-targeted genes in CWR22Rv1-fARKD cells. Dimethylcurcumin (ASC-J9) (5 or 10 µM) significantly suppresses the DHT-induced cell growth in all three PCa cell lines. Dimethylcurcumin (ASC-J9) suppresses AR-targeted genes and cell growth by degradation of fAR and ectopic AR3 in C81 and C4-2 cells. Dimethylcurcumin (ASC-J9) selectively promotes AR degradation by disrupting the interaction between AR and AR coregulators. ASC-J9 reduces the AR aggregated AR-112Q in cells. Dimethylcurcumin (ASC-J9) suppresses the aggregation of AR-112Q in SBMA PC12/AR-112Q cells.
Dimethylcurcumin (ASC-J9) (75 mg/kg, i.p.) degrades both fAR and AR3 in the xenografted tumors in vivo, and SC-J9-treated tumors has significantly decreased Ki67-positive cells. Dimethylcurcumin (ASC-J9) (50 mg/kg every 48 h, i.p.) substantially ameliorates the SBMA symptoms in AR-97Q mice, and ameliorates neuromuscular pathological findings. The Dimethylcurcumin (ASC-J9)-treated SBMA mice have relatively normal serum testosterone concentrations. ASC-J9-treated mice show significantly smaller prostate tumor sizes when compared with those receiving classic ADT/castration with little serum androgen.