洛替拉纳

中文名称洛替拉纳中文同义词洛替拉纳;乐替拉纳;莱洛尔;(S)-3-甲基-N-(2-氧代-2-((2,2,2-三氟乙基)氨基)乙基)-5-(5-(3,4,5-三氯苯基)-5-(三氟甲基)-4,5-二氢异恶唑-3-基)噻吩-2-甲酰胺;洛替拉纳-同位素-D4;洛替拉纳,10MMDMSO溶液英文名称Lotilaner英文同义词Lotilaner;(S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylicacid[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide;2-Thiophenecarboxamide,5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-;Parasite,Inhibitor,γ-AminobutyricacidReceptor,Lotilaner,inhibit,Gamma-aminobutyricacidReceptor,GABAReceptor;(S)-3-Methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide;Lotilaner(TP-05);Lotilaner,10mMinDMSOCAS号1369852-71-0分子式C20H14Cl3F6N3O3S分子量596.76EINECS号相关类别对照品;医药原料;医用原料;1Mol文件1369852-71-0.mol结构式洛替拉纳性质密度1.66±0.1g/cm3(Predicted)储存条件Storeat-20°C溶解度二甲基亚砜：≥100mg/ml（167.57mM）形态固体酸度系数(pKa)12.52±0.46(Predicted)颜色白色至米白色洛替拉纳用途与合成方法用途洛替拉纳是一种杀寄生虫剂，为有效、非竞争性的昆虫GABACl受体拮抗剂，洛替拉纳对果蝇γ－氨基丁酸受体的IC50值为23.84nM。洛替拉纳对家犬的γ-氨基丁酸A型受体无明显作用。生物活性Lotilaner是一种杀寄生虫剂，为有效、非竞争性的昆虫GABACl受体拮抗剂，对果蝇GABA受体的IC50值为23.84nM。对家犬的GABAA无明显作用。靶点IC50:23.84nM(DmS-GABA),38.25nM(DmR2-GABA),52.40nM(Ls-GABA1),36.79nM(Rm-GABA)体外研究LotilanershowsIC50sof38.25±3.75,52.40±4.54,36.79±4.39nMforDrosophilamelanogasterdieldrin/fipronil-resistantforms(DmR2),Lepeophtheirussalmonis(Ls)andRhipicephalusmicroplus(Rm)GABAClrecept