白鲜碱|T5746|TargetMol

Dictamine
484-29-7

￥670 20mg 起订

上海更新日期：2024-09-23

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 白鲜碱

英文名称：: Dictamine

CAS号：: 484-29-7

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.72%

产品类别：: 抑制剂

货号：: T5746

Product Introduction

Bioactivity

Name	Dictamine
Description	Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells.
Kinase Assay	Commercial oligonucleotide microarrays were used to determine the global transcriptional response of S. cerevisiae triggered by treatment with dictamnine. We interpreted our microarray data using the hierarchical clustering tool, T-profiler. Several major transcriptional responses were induced by dictamnine. The first was the induced environmental stress response, mainly under the control of the Msn2p and Msn4p transcription factors, and the repressed environmental stress response in genes containing the PAC (RNA polymerase A and C box) and rRPE (ribosomal RNA processing element) motifs. The second was the Upc2p-mediated response involved in lipid biosynthesis. The third comprised the PDR3- and RPN4-mediated responses involved in multidrug resistance (MDR). Finally, the TBP-mediated response was induced with dictamnine treatment. TBP is an essential general transcription factor involved in directing the transcription of genes. Quantitative real-time RT-PCR was performed on selected genes to verify the microarray results. Furthermore, morphological transitions during dictamnine exposure to S. cerevisiae L1190 (MATa/alpha) were examined, using confocal laser microscopy[1].
Animal Research	High performance centrifugal partition chromatography method was used for separation of the essential dictamnine,and anti-inflammatory effects of ethanol extracts and dictamnine were investigated by xylene-induced aruical swelling in mice and the abdominal capillary permeability in mice[3].
In vitro	Dictamnine 对模型真菌酿酒酵母具有抗菌活性，最小抑菌浓度(MIC)为64 microg/ml[1]。低浓度下Dictamnine(Dic)诱导S期细胞周期停滞，而高浓度下诱导细胞凋亡，此过程中未涉及线粒体膜电位(Δψmm)的丧失。使用特异性抑制剂z-DQMD-fmk抑制caspase-3并未减弱Dic诱导的凋亡。与仅用Dic处理相比，DHA与Dic的联合处理显著提高了凋亡细胞死亡率。预处理z-DQMD-fmk显著降低了DHA与Dic共同诱导的凋亡，暗示caspase-3在Dic与DHA共同诱导的细胞凋亡中起重要作用。Dic在低浓度下诱导S期细胞周期停滞，在高浓度下诱导细胞凋亡，此过程中未涉及线粒体和caspase，而DHA通过依赖caspase的途径增强了Dic诱导的A549细胞凋亡[2]。
In vivo	Dictamnine在多种抗炎动物模型中显示出不同的抗炎效果[3]。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 50 mg/mL (250.99 mM)
Keywords	Fungal \| inhibit \| Bacterial \| Dictamine \| Inhibitor \| Apoptosis
Inhibitors Related	Oleic acid \| Dehydroacetic acid sodium \| Doxycycline \| Methyl anthranilate \| Neomycin sulfate \| Dimethyl sulfoxide \| Dextran sulfate sodium salt (MW 4500-5500) \| Stavudine \| Ampicillin sodium \| Sulfamethoxazole sodium \| Kanamycin sulfate \| Sodium 4-phenylbutyrate
Related Compound Libraries	Bioactive Compound Library \| Anti-Cancer Active Compound Library \| Selected Plant-Sourced Compound Library \| Alkaloid Natural Product Library \| Ancient Chinese Classical Formulas Compound Library \| Food as Medicine Compound Library \| Anti-Tumor Natural Product Library \| Natural Product Library \| Natural Product Library for HTS \| Anti-infective Natural Product Library

白鲜碱|||Dictamnine|||Dectamine|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子