米非司酮|T1102|TargetMol

Mifepristone
84371-65-3

￥119 10mg 起订

￥178 25mg 起订

￥247 50mg 起订

上海更新日期：2025-10-31

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 米非司酮

英文名称：: Mifepristone

CAS号：: 84371-65-3

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.74%

产品类别：: 抑制剂

货号：: T1102

Product Introduction

Bioactivity

名称	Mifepristone
描述	Mifepristone (C-1073) is a progesterone-receptor (IC50=0.2 nM) and glucocorticoid-receptor antagonist (IC50=2.6 nM). Mifepristone is used to terminate pregnancy, treat uterine fibroids, and treat endometriosis.
细胞实验	Cell growth is evaluated in various ovarian cancer cell lines that are subjected to dose-response or time course treatments. Media containing each of the doses of fresh steroids is replaced every 24 hours. Control groups of cells are treated with vehicle ethanol at a final concentration of less than 0.05%. Number of viable cells is evaluated by trypsinization and counting in a hemocytometer chamber using trypan blue dye exclusion. Experiments are conducted in media without phenol red and supplemented with charcoal extracted fetal bovine serum, or media containing unextracted serum and having phenol red. Similar results are obtained with both media preparations; therefore, after performing the growth curves, all subsequent experiments are conducted using media with unextracted serum and in the presence of phenol red. When indicated, the proliferation IC50s are calculated using software designed to study drug interaction. (Only for Reference)
激酶实验	Glucocorticoid receptor (GR) antagonist activity, Progesterone receptor (PR) antagonist activity: T47D alkaline phosphatase assay: T47D human breast cancer cells are plated in 96-well tissue culture plates at 104 cells per well in assay medium [RPMI medium without phenol red containing 5% (v/v) charcoal-treated FBS and 1% (v/v) penicillin–streptomycin]. Two days later, the medium is decanted and Mifepristone or control is added at a final concentration of 0.1% (v/v) dimethylsulfoxide in fresh assay medium. Twenty-four hours later, an alkaline phosphatase assay is performed using a SEAP kit. The medium is decanted and the cells are fixed for 30 minutes at room temperature with 5% (v/v) formalin. The cells are washed once at room temperature with Hanks' buffered saline solution. Equal volumes (0.05 mL) of dilution buffer, assay buffer, and 1:20 substrate/enhancer mixture are then added. After 1-hour incubation in the dark at room temperature, the lysate is transferred to a white 96-well plate and luminescence is read using a LuminoSkan Ascen. A549 reporter assay: A549 human lung carcinoma cells are washed with OPTI-MEM I. The medium is removed and lipid–DNA complex solution (1.5 μg/mL of GRE-luciferase reporter DNA in 8.5 mL OPTI-MEM I plus 6 μL/mL DMRIE-C reagent in 8.5 mL OPTI-MEM I, combined, mixed and incubated at room temperature for 40 minutes) is overlayed onto the cells in a T160 flask. The cells are incubated for 16 hours at 37 °C in a CO2 incubator. The DNA-containing medium is removed and 30 mL of growth medium containing 5% (v/v) charcoal-treated fetal bovine serum is added. After 5-6 hours, the cells are seeded in 96-well plates and incubated overnight at 37 °C. Mifepristone is then added to each well followed by dexamethasone as a corticoid challenge. The cells are incubated for 24 hours. Luciferase assay buffer is added to each well and the cells are incubated for 30 minutes at room temperature.Luciferase activity is measured in a DYNEX Microlite plate on a TopCount.
体外活性	方法：人MCF7细胞用Mifepristone（1-100 μM）处理72小时，使用CCK-8方法检测细胞生长抑制情况。结果：Mifepristone抑制MCF7细胞生长（IC50=24.03 μM）。[1] 方法：卵巢癌细胞SK-OV-3 和 OV2008用Mifepristone（5、10、15、20 μM）处理3天，使用台盼蓝染色排除法（Sigma）评估存活细胞数量。结果：Mifepristone剂量依赖性地抑制SK-OV-3细胞（IC50=6.25 μM）和 OV2008细胞（IC50=6.91 μM）生长。[2]
体内活性	方法：为研究Mifepristone的抗肿瘤活性，将Mifepristone（2 mg/kg）皮下注射给人宫颈肿瘤异种移植裸鼠模型，持续3天。然后将Cisplatin（3 mg/kg）腹腔注射给裸鼠，持续3天。结果：仅用Cisplatin 治疗，肿瘤生长受到抑制。Cisplatin 和 Mifepristone 的组合使肿瘤重量减轻更显著，减轻了约 50%。[3] 方法：为研究Mifepristone的抗肿瘤活性，将Mifepristone（0.5、1 mg/kg）皮下植入给SK-OV-3卵巢癌细胞系在裸鼠中建立的皮下移植瘤模型。结果：Mifepristone以剂量依赖性方式显著抑制肿瘤生长，从治疗开始20天后开始观察到效果。[2] 方法：为研究Mifepristone的抗肿瘤活性，将Mifepristone（50 mg/kg）皮下注射给MKN-45胃癌细胞系在裸鼠中建立的皮下移植瘤模型。结果：Mifepristone显著减少了肺部转移灶的数量。在移植瘤中，Mifepristone下调了血管内皮生长因子（VEGF）和微血管密度（MVD）的表达。[4] 方法：为研究Mifepristone的抗肿瘤活性，将Mifepristone（15 mg/kg）皮下注射给SK-N-SH神经母细胞瘤细胞系在裸鼠中建立的皮下移植瘤模型，每周两次，共六次。结果：Mifepristone显著抑制了肿瘤生长，抑制率高达80%。Mifepristone治疗后肿瘤体积和重量显著减少。[5]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.3 mg/mL (10.01 mM), Suspension. DMSO : 45 mg/mL (104.75 mM), Sonication is recommended. Ethanol : 21.5 mg/mL (50 mM)), Heating is recommended.
关键字	RU-486 \| RU-38486 \| RU38486 \| RU 486 \| progestogenReceptor \| progestogen Receptor \| ProgesteroneReceptor \| Progesterone Receptor \| PR \| NR3C3 \| NOSynthase \| NOS \| NO Synthase \| Nitric oxide synthases \| Mifepristone \| Inhibitor \| inhibit \| GlucocorticoidReceptor \| Glucocorticoid Receptor \| EstrogenReceptor \| Estrogen Receptor \| C1073 \| C 1073 \| Autophagy
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米非司酮|||RU486|||RU 38486|||C-1073|TargetMol

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