硝羟喹啉|T0400|TargetMol

Nitroxoline
4008-48-4

￥99 1mL 起订

上海更新日期：2024-09-23

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 硝羟喹啉

英文名称：: Nitroxoline

CAS号：: 4008-48-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: ≥98%

产品类别：: 抑制剂

货号：: T0400

Product Introduction

Bioactivity

名称	Nitroxoline
描述	Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.
细胞实验	cell suspension are seeded in the wells of an E-plate 16 according to the manufacturer's instructions. After seeding, the CI is monitored every 15 min. After ∼10 h (MCF-10A neoT and MMTV-PyMT), 14 h (U-87 MG) or 24 h (LPB), when the cells are in their log phase of growth, 50 μl of the compound or 0.1% DMSO is added, and the experiment allowed to run for 72 h. Once every 24 h the medium is replaced with fresh medium containing the inhibitor or suitable control to prevent cell death due to medium depletion. Compounds and their concentrations are: nitroxoline (5 μM) and CA-074 (5 μM) for all cell lines other than MCF-10A neoT cell line, where nitroxoline was used at 2.5 μM. All measurements were performed in quadruplicate. (Only for Reference)
激酶实验	In Vitro Kinase Assays : The potency of SP600125 towards kinases, including MPS1, JNK, and Aurora kinase A, is determined based on the specific measurement of radioactive phosphotransfer to the substrate. For each enzyme, the absolute Km values for ATP and the specific substrate are initially determined and each assay is then run at optimized [ATP] (2·αKm) and [substrate] (5·Km) concentrations. MPS1 activity is measured using 5 nM of MPS1 recombinant protein in 50 mM HEPES pH 7.5, 2.5 mM MgCl2, 1 mM MnCl2, 1 mM DTT, 3 μM NaVO3, 2 mM β-glycerophosphate, 0.2 mg/mL BSA, 200 μM P38-βtide substrate-peptide (KRQADEEMTGYVATRWYRAE), and 8 μM ATP with 1.5 nM 33P-γ-ATP. Ten serial 1:3 dilutions (from 30 μM to 1.5 nM) of SP600125 are tested and IC50 determined.
体外活性	使用分光荧光测定法，Nitroxoline可明显减少所有受测癌症细胞株细胞外 DQ 胶原 IV 的降解。Nitroxoline 还能明显减少实时监测到的肿瘤细胞侵袭，并减少多细胞肿瘤球体的侵袭生长，这种肿瘤球体可用作肿瘤侵袭的三维玻璃体模型。在体外血管生成试验中，Nitroxoline可显著减少内皮管的形成[1]。
体内活性	Nitroxoline 在LPB纤维肉瘤和MMTV-PyMT乳腺癌小鼠模型中显著抑制了肿瘤生长、血管生成和转移[1]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 65 mg/mL (341.82 mM)
关键字	Nitroxoline \| Bacterial \| Antibiotic \| Autophagy \| inhibit \| Inhibitor
相关产品	Guanidine hydrochloride \| Naringin \| Doxycycline \| Neomycin sulfate \| Hydroxychloroquine \| Dimethyl sulfoxide \| Stavudine \| Ampicillin sodium \| Salicylic acid \| Sulfamethoxazole sodium \| Paeonol \| Kanamycin sulfate
相关库	抗癌上市药物库 \| 经典已知活性库 \| 已知活性化合物库 \| ReFRAME 相关化合物库 \| 药物片段库 \| 抗衰老化合物库 \| 上市药物库 \| 药物功能重定位化合物库 \| 人代谢物化合物库 \| 抗癌药物库

5-Nitro-8-quinolinol|||8-Hydroxy-5-nitroquinoline|||硝羟喹啉|||5-Nitro-8-hydroxyquinoline|||5-nitroquinolin-8-ol|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子