吡噻硫酮|T0153|TargetMol

Oltipraz
64224-21-1

￥255 5mg 起订

￥418 10mg 起订

￥614 25mg 起订

上海更新日期：2024-09-23

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 吡噻硫酮

英文名称：: Oltipraz

CAS号：: 64224-21-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.56%

产品类别：: 抑制剂

货号：: T0153

Product Introduction

Bioactivity

名称	Oltipraz
描述	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.
激酶实验	The Src and Abl kinase assays: The Src kinase activity is measured in an ELISA format. Src (3 units/reaction), reaction buffer (50 mM Tris-HCl pH 7.5, 10 mM MgCl2, 0.1 mM EGTA, 0.5 mM Na3VO4) and cdc2 substrate peptide are added to various concentration of Bosutinib and incubated at 30 °C for 10 minutes. The reaction is started by the addition of ATP to a final concentration of 100 μM, incubated at 30 °C for 1 hour and stopped by addition of EDTA. Instructions from the manufacturer are followed for subsequent steps. The Abl kinase assay is performed in a DELFIA solid phase europium-based detection assay format. Biotinylated peptide (2 μM) is bound to streptavidin-coated microtitration plates for 1.5 hours in 1 mg/mL ovalbumin in PBS. The plates are washed for 1 hour with PBS/0.1% Tween 80, followed by a PBS wash. The kinase reaction is incubated for 1 hour at 30°C. Abl kinase (10 units) is mixed with 50 mM Tris-HCl (pH 7.5), 10 mM MgCl2, 80 μM EGTA, 100 μM ATP, 0.5 mM Na3VO4, 1% DMSO, 1 mM HEPES (pH 7.0), 200 μg/mL ovalbumin and various concentration of Bosutinib. The reaction is stopped with EDTA at a final concentration of 50 mM. The reaction is monitored with Eu-labeled phosphotyrosine antibody and DELFIA enhancement solution.
体外活性	作为一种化学保护剂，Oltipraz 能以 Nrf2 依赖性方式诱导第二阶段解毒酶的活性。[1] 在人类 HT29 结肠癌细胞中，奥替普拉唑通过显著加速 HIF-1α 蛋白的降解，抑制胰岛素、缺氧或 CoCl2 对 HIF-1α 的诱导。[2]
体内活性	Oltipraz（500 mg/kg，口服）可显著降低野生型小鼠胃肿瘤的复发率 55%，但对 nrf2 缺失型小鼠的肿瘤负荷没有影响。[1] 在移植了 HCT116 细胞的 BALB/c 裸鼠体内，Oltipraz（200 mg/kg，口服）通过抑制 HIF-1α 抑制肿瘤生长和血管生成。[2] 在以 CDAA 为食的大鼠中，Oltipraz 可减轻非酒精性脂肪性肝炎相关纤维化的进展。[3]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 15 mg/mL (66.27 mM), Sonication is recommended.
关键字	Inhibitor \| HIF/HIF Prolyl-Hydroxylase \| Oltipraz \| Keap1-Nrf2 \| RP35972 \| inhibit \| HIFs \| Human immunodeficiency virus \| HIV \| Hypoxia-inducible factors \| NSC347901 \| NSC-347901 \| RP-35972 \| HIF-PH
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吡噻硫酮|||RP 35972|||NSC 347901|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子