化合物 A 769662|T2468|TargetMol

A-769662
844499-71-4

￥256 1mg 起订

￥365 2mg 起订

￥596 5mg 起订

上海更新日期：2026-05-08

TargetMol中国（陶术生物）

VIP14年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 化合物 A 769662

英文名称：: A-769662

CAS号：: 844499-71-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 98.36%

产品类别：: 抑制剂

货号：: T001|T2468

Product Introduction

Bioactivity

名称	A-769662
描述	A-769662 is a reversible AMPK activator with an EC50 value of 0.8 μM. A-769662 exhibits biological activities including metabolic regulation, antitumor effects, and anti-inflammatory properties. A-769662 can be used in metabolic and oncology drug research and development.
细胞实验	Cell viability of MEF cells treated or not with A-769662 is performed as follows: cells are harvested by trypsinization and incubated with 0.5 mg/mL RNase and 50 μg/mL propidium iodine at room temperature in the dark; cell viability is analyzed by flow cytometry using a FACScanto flow cytometer, using an excitation laser at 488 nm and a propidium iodine fluorescence detection at 600 nm. To determine the proportion of cells in each phase of the cell cycle, cells are harvested by trypsinization, collected by centrifugation, washed in PBS and fixed overnight in 80% ethanol at -20 °C. Subsequently, these fixed cells are centrifuged to remove the fixative and incubated for 20 minutes in the dark at room temperature in PBS containing 0.5 mg/mL RNase and 50 μg/mL propidium iodine. Flow cytometry analysis is performed as above. The proportion of cells in G1, S, and G2 is determined using the MODFIT program. Cell culture pictures are taken at the indicated times using a camera coupled to an inverted microscope with a 20 × objective. (Only for Reference)
激酶实验	96-well AMPK assay: AMPK activity is measured by monitoring phosphorylation of the SAMS peptide substrate (20 mM in standard assays and 100 mM in additivity assays) following a previously described protocol (Anderson et al., 2004). To determine whether A-769662-induced AMPK activation occurs in a reversible manner, AMP or A-769662 are preincubated with rat liver AMPK for 10 minutes at 20 times standard assay concentrations prior to dilution and measurement of AMPK activity.
体外活性	方法：小鼠 BMSCs 加入 10 μM A-769662，处理 6 天，分时间点检测，Western blot 检测 p-AMPKα （Thr172）和 p-ACC （Ser79）。结果：A-769662 显著增加 AMPKα及其底物 ACC 的磷酸化水平，确认激活 AMPK 信号。[1]
体内活性	方法：雄性 BALB/c 小鼠腹腔注射 LPS 2 mg/kg，4 小时后腹腔注射 A-769662 10 mg/kg，8 小时后处死小鼠。结果：A-769662 显著降低 Tlr-4 mRNA、MyD88 蛋白、TNF-α/IL-6 水平，同时增加 p-AMPK 和 p-ACC 水平。[2]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	Ethanol : 3.61 mg/mL (10.02 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.5 mg/mL (12.49 mM), Solution. DMSO : 51 mg/mL (141.51 mM), Sonication is recommended.
关键字	Inhibitor \| inhibit \| FattyAcidSynthase \| Fatty Acid Synthase \| FAS \| AMPK \| AMP-activated protein kinase \| A-769662 \| A769662
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A 769662;TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(14年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子