醋酸奥曲肽|T4119

Octreotide Acetate
79517-01-4

￥242 5mg 起订

￥413 10mg 起订

￥618 25mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 醋酸奥曲肽

英文名称：: Octreotide Acetate

CAS号：: 79517-01-4

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.87%

产品类别：: 抑制剂

货号：: T4119

Product Introduction

Bioactivity

名称	Octreotide Acetate
描述	Octreotide Acetate (Sandostatin) is a potent, long-acting synthetic somatostatin octapeptide analog that inhibits secretion of growth hormone.
动物实验	Octreotide (acetate) is formulated in saline.MiceThirty mice with HCC xenografts are randomLy divided into three groups: (A) Octreotide-soln group, (B) Octreotide-PPSG group, and (C) control group. Octreotide-soln group receives i.p. injection of 100 μg/kg octreotide-soln once a day and totally for consecutive 14 days. Octreotide-PPSG group receives a single subcutaneous injection of 1.4 mg/kg Octreotide-PPSG, and the injection volume is about 0.2 mL. Control group receives i.p. injection of saline once a day for consecutive 14 days. Treatment starts on the next day after injection of H22 hepatoma cell suspension and maintains for 14 days. Tumor growth is monitored by periodic caliper measurements on day 7 and day 14 post seeding. Tumor volumes (V) are calculated based on the length and width of tumor by Eq. RatTwelve male SD rats are divided into two groups, and housed in standard cages at 25°C, with free access to food and water for a week prior to the experiment. Rats are subcutaneously injected with Octreotidereotide solution (Octreotide-soln) or Octreotide-PPSG at an equivalent single dose of 20 mg/kg. The dose is determined based on the clinical dose of Octreotide-soln in human. Rats are fasted for 12 h before dosing and food is returned approximately 2 h post dosing. Blood samples are collected at predetermined time points using heparinized Eppendorf tubes. Immediately after collection, the blood samples are placed on ice until centrifuged at 3000 g for 10 min within 1 h. The plasma is collected and stored at ?20°C until analysis.
体内活性	Octreotide处理组与盐水组相比，肿瘤体积显著减少。Octreotide-PPSG（1.4 mg/kg，i.p.）的抗肿瘤效果超过Octreotide-soln（100 μg/kg，i.p.）。Octreotide处理在原发性HCC携带大鼠中显著抑制SSTR2和SSTR5的表达水平，与盐水组相比。Octreotide-PPSG对SSTR2和SSTR5的表达抑制作用大于Octreotide-soln处理组。 Octreotide Acetate 盐试验剂量在2小时内将血清胃泌素水平显著降低至基线的约三分之一，效果持续约6小时。第21天，开始使用持续释放配方的 Octreotide Acetate 盐（5 mg肌内注射，每4周一次）。
存储条件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 29 mg/mL
关键字	inhibit \| Octreotide \| SMS-201995 \| SMS201995 \| Inhibitor \| SSTR \| Somatostatin Receptor \| SSTRs \| Octreotide Acetate \| SMS 201-995
相关产品	Cyclosomatostatin Acetate \| BIM-23190 aceate \| CYN 154806 TFA \| FK962 \| 2-Aminoethanethiol \| Somatostatin acetate \| (1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid \| L-797,591 hydrochloride \| Cortistatin 14, human, rat acetate \| L-796,778 \| L-803087 \| Cortistatin-14 acetate
相关库	环肽库 \| JAK-STAT 化合物库 \| 多肽分子库 \| 临床前化合物库 \| NO PAINS 化合物库 \| 大环化合物库

醋酸奥曲肽|||SMS 201-995 (acetate)|||SMS 201995|||Sandostatin|||Longastatin|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子