咖啡酸乙酯|T5681

ETHYL CAFFEATE
102-37-4

￥289 10mg 起订

￥539 25mg 起订

￥877 50mg 起订

上海更新日期：2024-12-02

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产品详情:

中文名称：: 咖啡酸乙酯

英文名称：: ETHYL CAFFEATE

CAS号：: 102-37-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 97.79%

产品类别：: 抑制剂

货号：: T5681

Product Introduction

Bioactivity

名称	ETHYL CAFFEATE
描述	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related signaling, including IFN-γ, T-bet, STAT1, and STAT4.
细胞实验	Collagen was dissolved in 0.1 M acetic acid at 4°C overnight.?Male DBA/1 mice were immunized at the tail base with 125?μg of collagen emulsified in complete Freund's adjuvant (CFA) containing Mycobacterium tuberculosis strain H37Rv.?Each mouse was then boosted with the same amount of collagen plus CFA 21 days later (taken as day 0). Starting from day 9 for 10 consecutive days, the mice were administered daily with ECF (50?mg/kg) or methotrexate (2?mg/kg)
激酶实验	The proliferation of splenocytes or T cells in response to ConA, LPS, and anti-CD3/28 was measured by CCK-8 Kit.?Briefly, BALB/c splenocyte suspension (5?×?105 cells/well) was cultured with ConA (5?μg/ml), LPS (10?μg/ml), and anti-CD3 (5?μg/ml;?145-2C11) in the presence of ECF at indicated concentrations.?The cultures were incubated for 48?h, 20?μl of CCK-8 was then added to each well before the end of culture, and OD value was read at 450?nm.?The MTT method was used to measure the cytotoxicity of the sample.?Splenocytes (5?×?105 cells/well) were cultured in triplicates in the absence or presence of ECF in a 96-well flat-bottomed plate (Costar) for 48?h.?MTT (5?mg/ml) was pulsed for 4?h prior to the end of the culture.?Upon removal of MTT/medium, 150?μl of DMSO was added to each well, and the plate was agitated on an oscillator for 5?min to dissolve the precipitate.?The assay plate was read at 570?nm using a microplate reader.
体外活性	体内实验中，ETHYL CAFFEATE(ECF)处理显著减轻了胶原诱导性关节炎(CIA)的严重程度，抑制了IFN-γ和IL-6的分泌，并降低了CD11b+Gr-1+脾脏嗜中性白细胞的比例。同时，ECF处理在不明显影响Th17细胞和调节性T细胞发展的情况下，显著抑制了CD4+T细胞中IFN-γ的表达。
体内活性	Shikui X、Aixue Z、Zengjun G 等人研究显示，Ethyl Caffeate 通过抑制Th1免疫应答，有效缓解胶原诱导的关节炎[J]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 41 mg/mL (196.91 mM)
关键字	Nuclear factor-kappaB \| Inhibitor \| NF-κB \| Cyclooxygenase \| PGE synthase \| Prostaglandin E synthase \| COX \| ETHYL CAFFEATE \| inhibit \| Nitric oxide synthases \| NOS \| Nuclear factor-κB \| NO Synthase
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咖啡酸乙酯|||ETHYL 3,4-DIHYDROXYCINNAMATE|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子