恩贝酸|T6485

Embelin
550-24-3

￥423 10mg 起订

￥828 25mg 起订

￥1320 50mg 起订

上海更新日期：2025-10-31

TargetMol中国（陶术生物）

VIP13年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 恩贝酸

英文名称：: Embelin

CAS号：: 550-24-3

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.60%

产品类别：: 抑制剂

货号：: T6485

Product Introduction

Bioactivity

名称	Embelin
描述	Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
细胞实验	Cell growth is determined by the MTT-based assay using Cell Proliferation Reagent WST-1 according to the manufacturer's instruction. Cells (5000 cells/well) are grown in medium with 10% FBS, and various concentrations of Embelin are added to the cells. Four to five days later, WST-1 is added to each well and incubated for 1-3 h at 37 °C. Absorbance is measured with a plate reader at 450 nm with correction at 650 nm.(Only for Reference)
激酶实验	Fluorescence Polarization Competitive Binding Assay: Fluorescence polarization experiments are performed in Dynex 96-well, black, round-bottom plates. A 5 μL sample of Embelin dilutions in DMSO, and preincubated XIAP BIR3 protein (0.06 μM) and the N terminus of a Smac peptide (SM7F) (0.01 μM) in the assay buffer are added to 96-well plates to produce a final volume of 125 μL. For each assay, the bound peptide control containing XIAP BIR3 protein and SM7F (equivalent to 0% inhibition) and free peptide control containing only free SM7F (equivalent to 100% inhibition) were included. The plates were mixed and incubated at room temperature for 3 h to reach equilibrium.
体外活性	来自日本紫金牛草的Embelin是一种小分子抑制剂，能够结合到XIAP BIR3域，与此同时Smac和caspase-9也会与之结合。Embelin以剂量依赖的方式抑制PC-3和LNCap细胞的生长，其IC50值分别为3.7 μM和5.7 μM。而对于正常的PrEC细胞和WI-38细胞，Embelin的毒性较低，其IC50值分别为20.1 μM和19.3 μM。用25 μM和50 μM的Embelin处理PC-3细胞48小时后，分别有30%和75%的细胞发生凋亡。[1] Embelin还通过选择性抑制5-脂氧合酶（5-LO）和微粒体前列腺素E2合酶-1（mPGES-1）强效地抑制了烯酸类物质的生物合成，其IC50值分别为0.06 mM和0.2 mM。[2]
存储条件	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+90% Corn Oil : 2 mg/mL (6.79 mM), Sonication is recommeded. Ethanol : 2.9 mg/mL (9.85 mM), Heating is recommended. DMSO : 257.5 mg/mL (874.69 mM), Sonication is recommended.
关键字	XIAP \| squamous \| prostate \| ProstaglandinReceptor \| Prostaglandin Receptor \| Nuclear factor-κB \| Nuclear factor-kappaB \| NSC-91874 \| NSC91874 \| nonpeptidic \| NF-κB \| NFκB \| NF-kB \| NFkB \| mPGES-1 \| Inhibitor \| inhibit \| IAP \| growth \| Embelin \| death \| cell \| carcinoma \| cancer \| Autophagy \| Apoptosis \| 5-Lipoxygenase
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恩贝酸/恩贝灵|||恩贝酸|||NSC 91874|||Emberine|||Embelic acid|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子