益母草碱|T5S2102

Leonurine
24697-74-3

￥108 1mg 起订

￥139 2mg 起订

￥213 5mg 起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 益母草碱

英文名称：: Leonurine

CAS号：: 24697-74-3

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.55%

产品类别：: 抑制剂

货号：: T5S2102

Product Introduction

Bioactivity

名称	Leonurine
描述	Leonurine (SCM-198) is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.
细胞实验	Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL). After cells were incubated with various concentrations of leonurine, Oil Red O staining and high-performance liquid chromatography (HPLC) assays were utilized to detect cellular lipid accumulation and cholesterol content, respectively. Cellular cholesterol efflux was determined by liquid scintillation counting. The mRNA and protein levels of ATP-binding cassette transporter A1/G1 (ABCA1/G1), peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor α (LXRα) in foam cells were assessed using real-time quantitative PCR (RT-qPCR) and western blot analyses, respectively. Plasma triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels in apoE-/- mice were evaluated using enzymatic methods. The atherosclerotic lesion sizes and collagen contents in aortic roots were determined by Oil Red O and Masson's trichrome staining, respectively[1].
动物实验	Used the chronic mild stress mouse model to explore the antidepressant effects of leonurine and the potential mechanisms. Behavioral tests including sucrose preference test, forced swimming test, and tail suspension test were taken to evaluate depression symptoms. Moreover, the contents of monoamine neurotransmitters in hippocampus and prefrontal cortex were measured by high-performance liquid chromatography. Neuronal morphology was detected by transmission electron microscopy[2].
体外活性	Leonurine 显著抑制人类THP-1巨噬细胞衍生泡沫细胞中的脂质积累，并以浓度依赖的方式促进了3H-胆固醇外流。此外，ABCA1/G1、PPARγ和LXRα的mRNA和蛋白水平均被Leonurine提升，而这一效果被LXRα siRNA或PPARγ siRNA转染所减弱[1]。
体内活性	连续给药leonurine（60 mg/kg）4周显著缓解慢性轻度应激小鼠的抑郁样行为，包括提高蔗糖偏好度和在强迫游泳测试及尾悬挂测试中减少不动时间。进一步研究发现，leonurine（60 mg/kg）有效恢复慢性轻度应激小鼠海马和前额叶皮层中5-羟色胺、去甲肾上腺素和多巴胺的水平，并伴随海马神经元损伤的改善。此外，leonurine（60 mg/kg）显著抑制了慢性轻度应激小鼠体内促炎细胞因子白细胞介素-1β、白细胞介素-6和TNF-α的产生，并抑制了核因子kappa B信号通路[2]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : ＜1 mg/mL (insoluble or slightly soluble)
关键字	Autophagy \| inhibit \| Leonurine \| SCM198 \| Inhibitor \| SCM 198
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益母草碱|||盐酸益母草碱|||SCM-198|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子