24697-74-3
基本信息
益母草鹼
盐酸益母草碱
益母草碱盐酸盐
盐酸益母草碱一水合物
盐酸益母草碱(标准品)
益母草碱, 来源于益母草
益母草碱盐酸盐,益母草碱
盐酸益母草碱(益母草碱盐酸盐,益母草碱)
LEONURINE HYDROCHLORIDE 盐酸益母草碱
Leonurin
Leonurine
LEONURINE HCL
Leonurine (SCM-198)
leonurine hydrochloride
4-Guanidinobutyl syringate
4-Guanidino-1-butanol syringate
Leonurine hydrochloride USP/EP/BP
Leonurine Hydrochloride Monohydrate
物理化学性质
| 外观性状 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于益母草。 |
| 熔点 | 238 °C |
| 沸点 | 496.7±55.0 °C(Predicted) |
| 密度 | 1.29±0.1 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | DMSO：可溶，2mg/mL，澄清（加热） |
| 酸度系数(pKa) | 8.26±0.25(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
| InChIKey | WNGSUWLDMZFYNZ-UHFFFAOYSA-N |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| 危险品标志 | Xi |
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-24/25 |
| WGK Germany | 3 |
| 海关编码 | 29399990 |
应用领域
药理药效:1．对子宫的作用益母草碱对兔、猫、犬、豚鼠等多种动物的子宫均呈兴奋作用2．对循环系统的作用小剂量益母草碱对离体蛙心有增强收缩作用，使用大量时反呈抑制现象。这种抑制现象可能由于迷走神经末梢兴奋所致。
盐酸益母草碱价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | XW2473518001 | 盐酸益母草碱 | 24697-74-3 | 50MG | 83元 |
| 2024/04/30 | HY-N0741A | 盐酸益母草碱 Leonurine hydrochloride | 24697-74-3 | 10mM * 1mLin DMSO | 198元 |
| 2024/04/30 | XW2473518002 | 盐酸益母草碱 | 24697-74-3 | 250MG | 221元 |
常见问题列表
Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.
Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.