L-苹果酸|T4838

(S)-Malic acid
97-67-6

￥178 1mL 起订

上海更新日期：2025-03-12

TargetMol中国（陶术生物）

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产品详情:

中文名称：: L-苹果酸

英文名称：: (S)-Malic acid

CAS号：: 97-67-6

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.86%

产品类别：: 抑制剂

货号：: T4838

Product Introduction

Bioactivity

名称	(S)-Malic acid
描述	(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid, which contributes to the sourness of a green apple. Malic acid can make a wine taste tart, although the amount decreases with increasing fruit ripeness. (wikipedia). In its ionized form malic acid is called malate. Malate is an intermediate of the TCA cycle along with fumarate. It can also be formed from pyruvate as one of the anaplerotic reactions. In humans, malic acid is both derived from food sources and synthesized in the body through the citric acid cycle or Krebs cycle which takes place in the mitochondria. Malate's importance to the production of energy in the body during both aerobic and anaerobic conditions is well established. Under aerobic conditions, the oxidation of malate to oxaloacetate provides reducing equivalents to the mitochondria through the malate-aspartate redox shuttle. During anaerobic conditions, where a buildup of excess of reducing equivalents inhibits glycolysis, malic acid's simultaneous reduction to succinate and oxidation to oxaloacetate is capable of removing the accumulating reducing equivalents. This allows malic acid to reverse hypoxia's inhibition of glycolysis and energy production. In studies on rats it has been found that only tissue malate is depleted following exhaustive physical activity. Other key metabolites from the citric acid cycle needed for energy production were found to be unchanged. Because of this, a deficiency of malic acid has been hypothesized to be a major cause of physical exhaustion. Notably, the administration of malic acid to rats has been shown to elevate mitochondrial malate and increase mitochondrial respiration and energy production.
体外活性	研究表明，ME对于L. casei中(S)-Malic acid(L-苹果酸)的利用是必要的。此外，如果删除编码组氨酸激酶或TC系统的应答调节器的基因，会导致丧失在(S)-Malic acid上生长的能力，这说明相应的TC系统调控并对ME的表达是必需的。转录分析显示，maeE的表达在(S)-Malic acid存在的情况下被诱导，在葡萄糖存在的情况下被抑制，而TC系统的表达则是由(S)-Malic acid诱导并且不被葡萄糖抑制。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 27.5 mg/mL (205.09 mM)
关键字	HYDROXYSUCCINIC ACID \| inhibit \| Inhibitor \| Malic acid \| (S)-Hydroxybutanedioic acid \| (S)-E 296 \| (S) Malic acid \| Endogenous Metabolite \| (S)-Malic acid \| 2-Hydroxysuccinic acid \| L-Malic acid \| (S)Malic acid
相关产品	Oleamide \| p-Hydroxybenzaldehyde \| Guanidine hydrochloride \| Naringin \| Daidzein \| Glycerol \| Sucrose \| Oxalic acid dihydrate \| Ferulic Acid \| 3-Indoleacetic acid \| Thymidine \| Fumaric acid
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L-苹果酸|||L-(-)-Malic acid|||(S)-2-Hydroxysuccinic acid|||(S)-(-)-HYDROXYSUCCINIC ACID|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
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