卡莫司汀|T3091

Carmustine
154-93-8

￥137 2mg 起订

￥228 5mg 起订

￥328 10mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 卡莫司汀

英文名称：: Carmustine

CAS号：: 154-93-8

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.91%

产品类别：: 抑制剂

货号：: T3091

Product Introduction

Bioactivity

名称	Carmustine
描述	Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
激酶实验	The determination of Acetyl-CoAdependent N-acetylation of 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) are performed. Incubation mixtures in the assay system consists of a total volume of 90 μL: glial tumor cells cytosols, diluted as required, in 50 μL of lysis buffer (20 mM Tris/HCl, pH 7.5, 1 mM DTT and 1 mM EDTA), 20 μL of an Acetyl-CoA recycling mixture of 50 mM Tris-HCl (pH7.5), 0.2 mM EDTA, 2 mM DTT, 15 mM acetylcamitine, 2U/mL carnitine acetyltransferase, and AF or PABA at specific concentrations. The reactions are started by addition of 20 μL of Acetyl-CoA. The control reactions have 20 μL distilled water in place of Acetyl-CoA. For the single point activity measurements, the final concentration of AF or PABA is 0.1 mM and AcCoA is 0.5 mM. The reaction mixtures with or without specific concentrations of Carmustine and lomustine are incubated at 37°C for 10 min and stopped with 50 μL of 20% trichloroacetic acid for the PABA reactions, and 100 μL of acetonitrile for the AF reactions. All of the reactions (experiments and controls) are run in triplicate
动物实验	Carmustine is formulated in corn oil.RatsIndividual rats are weighted prior to enter the study; their weights are recorded, and they are randomLy assigned to four groups. Group I (saline group); This group consists of 12 rats. These rats are injected with 2 mL/kg of saline intraperitoneally (IP) 48 h before the study, being included by the study 48 h later. Group II (corn oil group) consists of 15 rats. These rats are injected with 2 mL/kg of corn oil (vehicle) IP 48 h before the study. Group III (Carmustine group) consists of 16 rats. These rats are injected with 1 mL per day of saline IP, administered at the same hour of the day as a single-dose for 3 days. Twelve hours after the first dose of saline, corn oil 2 mL/kg + Carmustine 25 mg/kg IP are injected, and the rats are included in the study 48 h after the administration of corn oil + Carmustine. Group IV (trimetazidine group) consists of 12 rats. These rats are injected with 2.5 mg/kg per day of trimetazidine (TMZ) IP, administered at the same hour of the day as a single-dose for 3 days. 12 h after the first dose of TMZ, corn oil 2 mL/kg + Carmustine 25 mg/kg IP are injected, and the rats are included in the study 48 h after the administration of corn oil + Carmustine
体外活性	Carmustine 是一种抗肿瘤化合物。在浓度为 8, 80, 和 800 μM 时，Carmustine 降低了大鼠神经胶质瘤细胞质和完整细胞中对2-氨基荧光素（AF）和对氨基苯甲酸（PABA）的N-乙酰转移酶（NAT）活性。同时，Carmustine 减少了DNA-AF 加合物的形成，尽管在大鼠神经胶质瘤细胞中DNA-AF 加合物的含量有所增加。
体内活性	Carmustine (BCNU；25 mg/kg，腹腔注射)在实验鼠中引起的肝重比（肝脏重量与体重的比值）和血浆结合胆红素水平均高于对照组，而胆汁流量、氧化型谷胱甘肽(GSSG)水平以及还原型谷胱甘肽(GSH)/GSSG比值则低于对照组。
存储条件	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 55 mg/mL (256.95 mM)
关键字	Carmustine \| DNA Alkylator/Crosslinker \| Inhibitor \| inhibit
相关产品	Methyl methanesulfonate \| Ifosfamide \| Cisplatin \| N-Nitroso-N-methylurea \| Streptozocin \| Temozolomide \| Busulfan \| Oxaliplatin \| Cyclophosphamide hydrate \| Cyclophosphamide \| Carboplatin \| Bendamustine hydrochloride
相关库	抗癌活性化合物库 \| 抗癌上市药物库 \| 经典已知活性库 \| EMA 上市药物库 \| 抗衰老化合物库 \| FDA 上市药物库 \| 药物功能重定位化合物库 \| 酪氨酸激酶分子库 \| 抗癌临床化合物库 \| 抗癌药物库

卡莫司汀|||Nitrumon|||Gliadel|||Carmubris|||bis-chloroethylnitrosourea|||BiCNU|||BCNU|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子