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网站主页 > 化工产品目录 >生物化工 > 抑制剂 > 蛋白酶体(Proteases) > Gamma-secretase 抑制剂 > DAPT

DAPT

基本信息 产品图片 产品描述 供应商联系方式 同类产品

基本信息:

  • 发布时间: 2017-06-12
  • 产品名称: DAPT
  • 产品英文名称: DAPT
  • CAS号: 208255-80-5
  • 产品包装: 10mg
  • 产品价格: 893元/罐
  • 有效期: 一年

产品图片:

DAPT

产品描述:

DAPT的生物活性

 

DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo.
IC50 value:
Target: γ-secretase
Does not effect APPα and APPβ levels. DAPT blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.

化学信息

分子量
432.46
储存条件
参考CoA中推荐的条件进行储存。
分子式
C23H26F2N2O4
CAS号
208255-80-5
溶剂/溶解度
DMSO ≥85mg/mL Water <1.2mg/mL Ethanol ≥85mg/mL

 

相关文献

 

[1]. El Mouedden et al (2006) Reduction in Abeta levels in Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors. Curr.Pharmaceut.Des. 12 671.

[2]. Munnamalai V, Hayashi T, Bermingham-McDonogh O.Notch prosensory effects in the Mammalian cochlea are partially mediated by fgf20.J Neurosci. 2012 Sep 12;32(37):12876-84.

[3]. Zhou JX, Han JB, Chen SM, Xu Y, Kong YG, Xiao BK, Tao ZZ.γ-secretase inhibition combined with cisplatin enhances apoptosis of nasopharyngeal carcinoma cells.Exp Ther Med. 2012 Feb;3(2):357-361. Epub 2011 Dec 6.

[4]. Yuan YY, Zeng ZY, Chen JM.[Effect of DAPT on Proliferation and Apoptosis of Human Multiple Myeloma Cell Line RPMI8226].Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jul;20(4):922-5.

[5]. Oikawa N, Goto M, Ikeda K, Taguchi R, Yanagisawa K.The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells.Neurosci Lett. 2012 Sep 6;525(1):49-53. Epub 2012 Jul 31.

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