格佐匹韦

中文名称格佐匹韦中文同义词格佐匹韦;格佐普韦;化合物GRAZOPREVIR;(33R,35S,91R,92R,5S)-5-(叔丁基)-N-((1R,2S)-1-((环丙基磺酰基)氨基甲酰基)-2-乙烯基环丙基)-17-甲氧基-4,7-二氧基-2,8-二氧杂-6-氮杂-1(2,3)-喹诺酮类-3(3,1)-吡咯烷-9(1,2)-环丙烷环十四烷-35-甲酰胺;MK-5172,HEPATITISCVIRUSNS3/4APROTEASE抑制剂英文名称MK5172英文同义词2)-ether;Grazoprevir;Grazoprevir/MK5172;(1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamidecyclic(1-2)-ether;MK5172;MK5172;(1R,18R,20R,24S,27S)-N-{(1R,2S)-1-[(Cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-7-methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.03,12.05,10.018,20]nonacosa-3,5,7,9,11-pentaene-27-carboxamide,potassiumsalt;GRAZOPREVIR;MK5172;MK-5172;(1R,18R,20R,24S,27S)-N-{(1R,2S)-1-[(Cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-7-methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.03,12.05,10.018,20]nonacosa-3,5,7,9,11-pentaene-27-carboxamide,potassiuCAS号1350514-68-9分子式C38H50N6O9S分子量766.9EINECS号相关类别代谢;APIMol文件1350514-68-9.mol结构式格佐匹韦性质密度1.38±0.1g/cm3(Predicted)储存条件Sealedindry,Storeinfreezer,under-20°C溶解度DMSO中≥38.35mg/mL；不溶于水；≥24mg/mL，乙醇溶液，温和加热和超声波形态固体酸度系数(pKa)4.48±0.40(Predicted)颜色白色至米白色格佐匹韦用途与合成方法生物活性Grazopreviranhydrous(MK5172)是一种HepatitisCVirusNS3/4AProtease的抑制剂，HCVgenotype1a、1B和4的IC50值分别为7pM、4pM和62pM