aladdin 阿拉丁 T414087 3-TYP 120241-79-4 99%

中文名：3-TYP

英文名：3-TYP

纯度：Moligand™，≥99%

货号：T414087

Cas号：120241-79-4

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selectiveSIRT3inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.

Targets

SIRT3 (cell-free); SIRT1 (cell-free); SIRT2 (cell-free) 16 nM; 88 nM; 92 nM

In vitro

Melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity are significantly attenuated by 3-TYP in HepG2 cells exposed to Cd (cadmium).

Cell Research(from reference)

Cell lines：HepG2 cells 

Concentrations：50 μM 

Incubation Time：12 h 

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