IL1R2/IL1RB重组蛋白-ACROBiosystems百普赛斯

IL-1 RII产品信息

别称：CD121b,IL1RB,IL1R2,CDw121b

物种：Human

属性：Protein

标记：Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>98% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

IL-1 RII分子背景

白细胞介素-1受体2型（IL1R2）也被称为CD121抗原样家族成员B（CDw121b），IL-1 II型受体，IL-1受体II型，属于白细胞介蛋白-1受体家族。已经鉴定出能够特异性结合IL1的两种不同类型的IL1受体，分别命名为IL1RI（IL1RA）和IL1RII（IL1RB）。IL1R2是IL1A、IL1B和IL1RN的非信号受体，可降低IL1B活性。通过与IL1B竞争性结合并阻止其与IL1R1结合，充当诱饵受体。IL1R2在与IL1B结合后通过与IL1RAP的非信号关联调节细胞反应。IL1R2（膜型和分泌型）优先结合IL1B，弱结合IL1A和IL1RN。分泌型IL1R2以高亲和力招募分泌型IL1RAP；这种复合物的形成可能是分泌/可溶性受体中和IL1B的主要机制。