Recombinant Murine sTNF RII/TNFRSF1B

Species

Gene ID

Accession

Source

Length

MW

Tag

Mouse

21938

P25119

E. coli

236aa

25.3kDa

－

About this Antibody

Name

Recombinant Murine sTNF RII/TNFRSF1B (Recombinant Murine soluble Tumor Necrosis Factor Receptor Type II/TNFRSF1B; rMusTNF RII/TNFRSF1B)；Recombinant Mouse sTNF RII/TNFRSF1B ; 重组小鼠可溶性肿瘤坏死因子受体II型/TNFRSF1B

Synonyms

CD120b; TNFRSF1B; CD120b; CD120b antigen; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR; soluble TNFR1B variant 1; TNFBRp80 TNF-alpha receptor; TNF-R2; TNFR2TNFR1B; TNF-R75; TNFR80; TNF-RII; TNF-R-II; TNFR-II; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 2μg/ml, corresponding to a specific activity of >500IU/mg in the presence of 0.1ng/ml of rMuTNF-α.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered solution in PBS, pH7.4.

Endotoxin

Less than 0.1EU/μg of rMusTNF RII/TNFRSF1B as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

TNFRSF1B also known as tumor necrosis factor receptor 2 (TNFR2) and CD120b, is encoded by the TNFRSF1B gene in humans. It is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. TNFRSF1B has been shown to interact with TRAF2 and TTRAP. Recombinant murine TNFRSF1B is a 25.3kDa protein with 236 amino acid residues.

Amino Acid Sequence

VPAQVVLTPY KPEPGYECQI SQEYYDRKAQ MCCAKCPPGQ YVKHFCNKTS DTVCADCEAS MYTQVWNQFR TCLSCSSSCT TDQVEIRACT KQQNRVCACE AGRYCALKTH SGSCRQCMRL SKCGPGFGVA SSRAPNGNVL CKACAPGTFS DTTSSTDVCR PHRICSILAI PGNASTDAVC APESPTLSAI PRTLYVSQPE PTRSQPLDQE PGPSQTPSIL TSLGSTPIIE QSTKGG

产品编号

产品名称

包装

P6065-5μg

Recombinant Murine sTNF RII/TNFRSF1B

5μg

P6065-20μg

Recombinant Murine sTNF RII/TNFRSF1B

20μg

P6065-100μg

Recombinant Murine sTNF RII/TNFRSF1B

100μg

P6065-1mg

Recombinant Murine sTNF RII/TNFRSF1B

1mg

-

说明书

1份