aladdin 阿拉丁 Y413992 YU238259 1943733-16-1 99%

中文名：YU238259

英文名：YU238259

纯度：≥99%

货号：Y413992

Cas号：1943733-16-1

存储温度：避光,-20°C储存

运输条件：超低温运输

产品介绍：

Information

YU238259 YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR) , but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.

Targets

HDR

In vitro

YU238259 exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects. Treatment with YU238259 is not only synergistic with ionizing radiation (IR), etoposide, and PARP inhibition, but this synergism is heightened by BRCA2-deficiency. Synthetic lethality of YU238259 in HDR-deficient cells results from accumulation of unresolved DSBs following additional inhibition of residual HDR pathway activity. Inhibition of HDR activity by YU238259 has little to no effect on the NHEJ pathway. YU238259 sensitizes tumor cells to radiation therapy and DSB-inducing chemotherapy .

In vivo

Growth of BRCA2-deficient human tumor xenografts in nude mice is significantly delayed by YU238259 treatment even in the absence of concomitant DNA-damaging therapy.

Cell Research(from reference)

Cell lines：U2OS cells 

Concentrations：25 μM 

Incubation Time：1 h 

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