aladdin 阿拉丁 M408199 4,6-二(4-吗啉基)-N-(4-硝基苯基)-1,3,5-三嗪-2-胺 326914-06-1 10mM in DMSO

中文名：4,6-二(4-吗啉基)-N-(4-硝基苯基)-1,3,5-三嗪-2-胺

英文名：MHY1485

英文别名：4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

纯度：10mM in DMSO

货号：M408199

包装：1ml

Cas号：326914-06-1

存储温度：-80℃储存

产品介绍：

Information

MHY1485 MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy .
In vitro

MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner. MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

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