aladdin 阿拉丁 E409275 Elimusertib (BAY-1895344) hydrochloride 1876467-74-1 10mM in DMSO

中文名：Elimusertib (BAY-1895344)

英文名：Elimusertib (BAY-1895344)

纯度：Moligand™，≥98%

货号：E414498

Cas号：1876467-74-1

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Elimusertib (BAY-1895344) is a very potent and highly selectiveATR (ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.

Targets

ATR (Cell-free assay) 7 nM

In vitro

BAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines.

In vivo

BAY 1895344 exhibits strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.

Cell Research(from reference)

Cell lines：HT-29 cells, M059J cells, 38 cancer cell lines 

Concentrations：3–300 nM 

Incubation Time：72 to 96 hours 

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