aladdin 阿拉丁 M414307 甲磺酸米托醌（米托Q10） 845959-50-4 97%

中文名：甲磺酸米托醌（米托Q10）

英文名：Mitoquinone (MitoQ10) mesylate

纯度：≥97%

货号：M414307

Cas号：845959-50-4

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Mitoquinone (MitoQ10) mesylate Mitoquinone mesylate (MitoQ, MitoQ10, Mitoubiquinone) is a TPP-based, mitochondria -targeted antioxidant that blocks H 2 O 2 -induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.

Targets

mitochondria ; ROS

In vitro

Mitoquinone blocks H2O2-induced intracellular ROS responses inmurine pancreatic acinar cells. Mitoquinone does not reduce mitochondrial depolarisation induced by either cholecystokinin (CCK) or bile acid TLCS. Mitoquinone increases basal and CCK-induced cell death in a plate-reader assay.

In vivo

In a TLCS-induced AP model Mitoquinone treatment is not protective. In AP induced by caerulein hyperstimulation (CER-AP), Mitoquinone exerts mixed effects. Thus, partial amelioration of histopathology scores is observed but without reduction of the biochemical markers pancreatic trypsin or serumamylase. Lungmyeloperoxidase and interleukin-6 are concurrently increased by Mitoquinone in CER-AP. Mitoquinone causes biphasic effects on ROS production in isolated polymorphonuclear leukocytes, inhibiting an acute increase but elevating later levels.

Cell Research(from reference)

Cell lines：Pancreatic Acinar Cells 

Concentrations：1 μM, 10 μM 

Incubation Time：200 s, 400 s, 600 s, 800 s, 1000 s 

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