aladdin 阿拉丁 Q408865 奎西诺司他（JNJ-26481585）2HCl 875320-31-3 10mM in DMSO

中文名：奎西诺司他（JNJ-26481585）2HCl

英文名：Quisinostat (JNJ-26481585) 2HCl

英文别名：N-hydroxy-2-(4-(((1-methyl-1H-indol-3-yl)methylamino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide dihydrochloride

纯度：10mM in DMSO

货号：Q408865

包装：1ml

Cas号：875320-31-3

存储温度：-80℃储存

产品介绍：

Information

Quisinostat (JNJ-26481585) 2HCl is a novel second-generationHDACinhibitor with highest potency for HDAC1 withIC50of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lo
In vitro

JNJ-26481585 exhibits broad spectrum antiproliferative activity in solid and hematologic cancer cell lines, such as all lung, breast, colon, prostate, brain, and ovarian tumor cell lines, with IC50 ranging from 3.1-246 nM, which is more potent than vorinostat, R306465, panobinostat, CRA-24781, or mocetinostat in various human cancer cell lines tested. A recent study shows that JNJ-26481585 promotes myeloma cell death at low nanomolar concentrations by resulting in Mcl-1 depletion and Hsp72 induction.

In vivo

In an HDAC1-responsive A2780 ovarian tumor screening model, JNJ-26481585 dosing at its maximal tolerated dose (10 mg/kg i.p. and 40 mg/kg p.o.) for 3 days leads to an HDAC1-regulated fluorescence , which predicts tumor growth inhibition. Furthermore, JNJ-26481585 also shows more potent inhibitory effects on the growth of C170HM2 colorectal liver metastases than 5-fluorouracil/Leucovorin.
Cell Data

cell lines：

Concentrations：0-300 nM

Incubation Time：24 hours

Powder Purity:≥99%

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/Q408865.html