aladdin 阿拉丁 P413982 PT2399 1672662-14-4 98%

中文名：PT2399

英文名：PT2399

纯度：≥98%

货号：P413982

Cas号：1672662-14-4

存储温度：-20°C储存,充氩

运输条件：超低温运输

产品介绍：

Information

PT2399 PT2399 is a potent and orally available antagonist of HIF-2 that selectively disrupts the heterodimerization of HIF-2α with HIF-1β .

Targets

HIF-2α ; HIF-1β

In vivo

PT2399 dissociates HIF-2 (an obligatory heterodimer [HIF-2α/HIF-1β])14 in human Clear cell Renal Cell Carcinoma (ccRCC) suppressing tumorigenesis in 56% (10/18) lines. PT2399 has greater activity than sunitinib, is active in sunitinib-progressing tumors, and is better tolerated. Illustrating drug specificity, gene expression is largely unaffected by PT2399 in resistant tumors. Sensitive tumors exhibits a distinguishing gene expression signature, and generally higher HIF-2α levels. Prolonged PT2399 treatment leads to resistance.

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