aladdin 阿拉丁 D413219 达卡他韦二盐酸盐 1009119-65-6 99%

中文名：达卡他韦二盐酸盐

英文名：Daclatasvir Dihydrochloride

纯度：≥99%

货号：D413219

Cas号：1009119-65-6

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Daclatasvir Dihydrochloride Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection.

Targets

NS5A

In vitro

Daclatasvir exhibited potent inhibition in all of the wild-type replicons and hybrid replicons representing the range of genotypes and subtypes. daclatasvir induces an alteration in the subcellular localization of NS5A, which inhibits the formation and activation of HCV RCs. Daclatasvir was found to have a high potency across all HCV genotypes with half-maximum effective concentrations (EC50) ranging from 9 to 146 pM. While it is pangenotypic, it has a low barrier to resistance against the subtype of Genotype 1a.

In vivo

Daclatasvir has good bioavailability in rats, dogs and cynomolgus monkey (F%= 50, 108 and 38 respectively).

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