Flt-3/CD135蛋白-ACROBiosystems百普赛斯

Flt-3产品信息

英文名称：Tyrosine-protein kinase receptor FLT3

中文名称：酪氨酸蛋白激酶受体FLT3

靶点别称：Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3

物种：Human/Mouse/Cynomolgus

属性：Protein

标记：Biotin-labeled/FITC Labeled/Unconjugated

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

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Flt-3分子背景

Flt-3（受体型酪氨酸蛋白激酶FLT3）也被称为FLK-2（胎儿肝激酶-2）、STK-1（干细胞酪氨酸激酶1）、CD135。FLT3是一种细胞因子受体，属于受体酪氨酸激酶III类。酪氨酸蛋白激酶作为细胞因子FLT3LG的细胞表面受体，调节造血祖细胞和树突状细胞的分化、增殖和存活。促进SHC1和AKT1的磷酸化，以及下游效应子MTOR的激活。促进RAS信号传导的激活和下游激酶的磷酸化，包括MAPK1/ERK2和/或MAPK3/ERK1。引起组成型激酶活性的突变通过激活多种信号通路促进细胞增殖和抗凋亡。