165393-06-6

中文名称尿石素C中文同义词尿石素C;3,8,9-三羟基-6H-苯并[C]色烯-6-酮英文名称UrolithinC英文同义词3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one;UrolithinC;3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one,3,8,9-trihydroxy-;Uro-C;insulin,Cachannels,Apoptosis,Polyphenols,ROS,mitochondria,anti-diabetic,gut-microbial,ReactiveOxygenSpecies,Inhibitor,EndogenousMetabolite,glucose-dependent,metabolite,CalciumChannel,β-cells,UrolithinC,ERK1/2,Ca2+channels,inhibit;UrolithinC(synthetic)CAS号165393-06-6分子式C13H8O5分子量244.2EINECS号相关类别对照品;HR140137Mol文件165393-06-6.mol结构式尿石素C性质熔点>300°C沸点605.4±55.0°C(Predicted)密度1.640±0.06g/cm3(Predicted)储存条件Inertatmosphere,RoomTemperature溶解度可溶于DMSO（轻微）、甲醇（轻微、加热）酸度系数(pKa)7.51±0.20(Predicted)形态固体颜色灰白色至浅棕色稳定性吸湿性LogP1.615(est)尿石素C用途与合成方法生物活性UrolithinC，是鞣花酸的多酚类肠道微生物代谢产物，是胰岛素分泌(insulinsecretion)的葡萄糖依赖性激活剂。UrolithinC是一种L型Ca2+通道开放剂，可增强Ca2+的流入。UrolithinC通过线粒体介导的途径诱导细胞凋亡(apoptosis)，并刺激活性氧(ROS)的形成。靶点InsulinsecretionL-typeCa2+channelReactiveoxygenspecies(ROS)Apoptosis体外研究UrolithinC(20-100μM;1hour;INS-1cells)treatmentenhancesglucose-inducedextracellularsignal-regulatedkinases1/2(ERK1/2)activationinINS-1β-cells.UrolithinCsignificantlyinhibitstheproliferationofPC12cells.UrolithinCtreatmentactivelyincreasesthelactatedehydrogenase(LDH)releaseandlipidperoxidationmalondialdehyde(MDA),stimulatesreactiveoxygenspecies(ROS)formationandmitochondrialmembranedepolarization,andcausedcalciumdyshomeostasis.UrolithinCtreatmentinducesapoptosisandSphasecellcyclearrest.WesternBlotAnalysisCellLine:INS-1cellsConcentration:20μM,100μMIncubationTime:1hourResult:Enhancedglucose-inducedextracellularsignal-regulatedkinases1/2(ERK1/2)activation.体内研究ThepharmacokineticsofUrolithinC(10mg/kg;intraperitonealadministration)inmaleWistarrat(140-160g)arestudied.Thehalf-lifeoftheterminalpartis11.3handthetotalclearance(CL/F)is3.41L/h/kg.Theinitialvolumeofdistribution(V1/F)andthesteady-statevolumeofdistribution(Vss/F)are0.831L/kgand55.6L/kg,respectively.安全信息MSDS信息尿石素C价格(试剂级)更新日期产品编号产品名称CAS编号包装价格2023/10/26HY-135897UrolithinC5mg620元2023/10/26HY-135897尿石素CUrolithinC165393-06-610mM*1mLinDMSO680元尿石素C上下游产品信息