DKK1重组蛋白，ACROBiosystems百普赛斯

DKK1产品信息

英文名称：Dickkopf-related protein 1

中文名称：Dickkopf相关蛋白-1

靶点别称：DKK1,SK

物种：Human / Mouse

属性：Protein

标记：Biotin-labeled / Unconjugated

内毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

无菌（Sterility）

The sterility testing was performed by membrane filtration method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

DKK1分子背景

dickkopf相关蛋白家族（DKK-1、-2、-3和-4）的成员是分泌蛋白，具有两个富含半胱氨酸的结构域，由接头区隔开。DKK1通过抑制WNT信号通路参与胚胎发育，以高亲和力与LRP6结合，并阻止Frizzled-WNT-LRP6复合物对Wnts的反应形成。DKK1与细胞表面受体Kremen形成三元复合物时，促进LRP6内化和降解。DKK1在发育过程中不仅起头部诱导剂的作用，还调节关节重塑和骨形成，这表明DKK1在类风湿性关节炎和多发性骨髓瘤的发病机制中起着重要作用。最近的研究报告称，DKK1从一个确定的发育时间点开始影响眼睛发育，并且通过β-catenin介导的Pdgfrα和E-cadherin表达对晶状体与表面外胚层的分离至关重要。