aladdin 阿拉丁 T425282 甲苯磺丁脲 64-77-7 10mM in DMSO

中文名：甲苯磺丁脲

英文名：Tolbutamide

中文别名：甲糖宁

英文别名：NSC 23813|Orinase|Tolylsulfonylbutylurea|CAS-64-77-7|tolbutamide|U 2043|3-butyl-1-(4-methylbenzenesulfonyl)urea|DTXCID801359|N-4-Methylbenzolsulfonyl-N-butylurea|SMR000058363|Tolbutamida|Tolbutamidum [INN-Latin]|1-p-Toluenesulfonyl-3-butylurea|Diabuton|DT

纯度：10mM in DMSO

货号：T425282

包装：1ml

Cas号：64-77-7

存储温度：-80℃储存

产品介绍：

Tolbutamide is a sulfonylurea agonist for secretion of insulin by beta-cells. In rat pancreatic beta-cells cultured in the presence of Tolbutamide displayed increased numbers of beta-cells in a dose responsive manner with beta-cell numbers doubling at 100 μg/ml of Tolbutamide. The compound displayed inhibitory action towards beta-cells at concentrations greater than 100 μg/ml. In addition in the presence of low glucose concentrations Tolbutamide’s cytotrophic action was inhibited. On isolated dog pancreas islets Tolbutamide at 180 μM stimulated the release of somatostatin, insulin and glucagon in the absence of glucose. in all situations the loss of Ca2+ eliminated all effects of Tolbutamide. The compound has been observed to mechanistically enhance the secretion of insulin by highly selective amplification of insulin secretory burst mass.

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