aladdin 阿拉丁 T407900 Tolterodine tartrate 124937-52-6 10mM in DMSO

中文名：Tolterodine tartrate

英文名：Tolterodine tartrate

英文别名：PNU-200583E;2-​[(1R)​-​3-​[bis(1-​methylethyl)​amino]​-​1-​phenylpropyl]​-​4-​methyl-phenol​, (2R,​3R)​-​2,​3-​dihydroxybutanedioat​e (1:1)

纯度：10mM in DMSO

货号：T407900

包装：1ml

Cas号：124937-52-6

存储温度：-80℃储存

产品介绍：

Information

Tolterodine tartrate Tolterodine tartrate (PNU-200583E) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.
In vitro

Tolterodine has a high affinity and specificity for muscarinic receptors in vitro and it exhibits selectivity for the urinary bladder over salivary glands in vivo. Tolterodine is a new muscarinic receptor antagonist intended for the treatment of urinary urge incontinence and other symptoms related to an overactive bladder. Tolterodine effectively inhibits carbachol-induced contractions of isolated strips of urinary bladder from guinea pigs in a concentration-dependent, competitive manner. Tolterodine binds with high affinity to muscarinic receptors in urinary bladder (Ki 2.7 nM), heart (Ki 1.6 nM), cerebral cortex (Ki 0.75 nM) and parotid gland (Ki 4.8 nM) from guinea pigs and in urinary bladder from humans (Ki 3.3 nM).

In vivo

Tolterodine (1 mg/kg, i.v.) is significantly more potent in inhibiting acetylcholine-induced urinary bladder contraction than electrically-induced salivation in the anaesthetised cat. Tolterodine administered intravenously increases the mean micturition interval, bladder capacity and micturition volume in normal rats and resiniferatoxin treated rats. Tolterodine (2 nM/kg) significantly increases bladder capacity (BC) in saline vehicle- cerebral infarct rats without increasing residual volume but it has no effects on BC in resiniferatoxin- cerebral infarct rats. Tolterodine tartrate (0.1 and 1.0 mg/kg) significantly decreases the number and amplitude of non-voiding contractions by 38-74% and 29-44%, respectively, and increases bladder capacity by 19-51% in female rats with bladder outlet obstruction.
Cell Data

cell lines：

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Incubation Time：

Powder Purity:≥99%

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