aladdin 阿拉丁 R408393 雷诺嗪二盐酸盐 95635-56-6 10mM in DMSO

中文名：雷诺嗪二盐酸盐

英文名：Ranolazine 2HCl

英文别名：RS-43285;N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride

纯度：10mM in DMSO

货号：R408393

包装：1ml

Cas号：95635-56-6

存储温度：-80℃储存

产品介绍：

Information

Ranolazine 2HCl Ranolazine 2HCl (RS-43285) is a calcium uptake inhibitor via the sodium/calcium channal , used to treat chronic angina.
In vitro

Ranolazine\xa0selectively inhibits\xa0late\xa0I(Na), reduces [Na(+)](i)-dependent calcium overload and attenuates the abnormalities of ventricular repolarisation and contractility that are associated with ischaemia/reperfusion and heart failure in myocardial cells. Ranolazine\xa0significantly and reversibly shortens the action potential duration (APD) of\xa0myocytes\xa0stimulated at either 0.5 Hz or 0.25 Hz in a concentration-dependent manner in left ventricular myocytes of dogs.\xa0Ranolazine\xa0at 5 and 10 mM reversibly shortens the duration of twitch\xa0contractions\xa0(TC) and abolished the after\xa0contraction. Ranolazine\xa0is found to bind more tightly to the inactivated state than the resting state of the\xa0sodium\xa0channel underlying I(NaL).

In vivo

Ranolazine\xa0(10 mM) significantly increases\xa0glucose\xa0oxidation\xa01.5-fold to 3-fold under conditions in which the contribution of\xa0glucoseto overall ATP production is low (low Ca, high FA, with insulin), high (high Ca, low Fa, with pacing), or intermediate in working\xa0hearts. Ranolazine\xa0similarly increases glucose\xa0oxidation in\xa0normoxic\xa0Langendorff\xa0hearts\xa0(high Ca, low FA; 15 mL/min). Ranolazine\xa0also significantly increases it during flow reduction to 7 mL/min, 3 mL/min, and 0.5 mL/min. Ranolazine\xa0significantly improves functional outcome, which is associated with significant increases in\xa0glucoseoxidation, a reversal of the increased FA\xa0oxidation\xa0seen in control reperfusions (versus preischemic), and a smaller but significant increase in glycolysis in\xa0reperfuse dischemic\xa0working\xa0hearts.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

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