aladdin 阿拉丁 P409237 Pazopanib HCl (GW786034 HCl) 635702-64-6 10mM in DMSO

中文名：Pazopanib HCl (GW786034 HCl)

英文名：Pazopanib HCl (GW786034 HCl)

英文别名：5-(4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide hydrochloride

纯度：10mM in DMSO

货号：P409237

包装：1ml

Cas号：635702-64-6

存储温度：-80℃储存

产品介绍：

Information

Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor ofVEGFR1,VEGFR2,VEGFR3, PDGFR, FGFR, c-Kit and c-Fms withIC50of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cel
In vitro

Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM. Pazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1\u2009µg/mL of Pazopanib and is completely abolished at 5\u2009µg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability.

In vivo

The mice treated with 30 mg/kg or 100\u2009mg/kg Pazopanib reveals a significant decrease in tumor burden compared with the mice treated with vehicle or 10\u2009mg/kg Pazopanib. Treatment with Pazopanib is well-tolerated and there is no significant difference in the body weight among the mice in each group.
Cell Data

cell lines：

Concentrations：0-10 μM

Incubation Time：1 hour

Powder Purity:≥99%

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/P409237.html