aladdin 阿拉丁 O407962 奥扎格雷盐酸盐 水合物 78712-43-3 10mM in DMSO

中文名：奥扎格雷盐酸盐 水合物

英文名：Ozagrel HCl

英文别名：OKY-046 HCl;(2E)​-3-​[4-​(1H-​imidazol-​1-​ylmethyl)​phenyl]​-​2-​propenoic acid,hydrochloride (1:1)

纯度：10mM in DMSO

货号：O407962

包装：1ml

Cas号：78712-43-3

存储温度：-80℃储存

产品介绍：

Information

Ozagrel HCl (OKY-046) is a selectivethromboxane A(2) (TXA(2)) synthetase inhibitor withIC50of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
In vitro

In vivo

Ozagrel prevents oleic acid (OA) induced thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 andinterleukin-8 mRNA expression in the whole lung of guinea pigs. Ozagrel (3 mg/kg) decreases both the area and volume of the cortical infarction after ischemia-reperfusion of the middle cerebral artery in rat. Ozagrel also has suppressive effects on the neurologic deficits in the microthrombosis rat model. Ozagrel improves the reduced spontaneously locomotor activity and the obstruction of motor coordination in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel suppresses the decrease in specific gravity of the brain tissue induced by the occlusion-reperfusion in the conscious cerebral ischemia-reperfusion SHR model, and recovers the postischemic decrease in cortical PO(2) after middle cerebral artery occlusion-reperfusion in cats. Ozagrel also increases the level of 6-keto-PGF(1alpha), a metabolite of prostaglandin I(2) (PGI(2)), in the brain tissue after cerebral ischemia-reperfusion, and the administration of PGI(2) improves the reduced spontaneous locomotor activity in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel administered intravenously 30 min before oleic acid injection prevents the decrease in Pao(2) and pulmonary vascular hyper-permeability in guinea-pigs. Ozagrel also prevents increases in lactate dehydrogenase activity, a measure of lung cell injury, TXB(2) and its weight ratio to 6-keto prostaglandin F(1alpha) in bronchoalveolar lavage fluid in guinea-pigs.
Cell Data

cell lines：Various NSCLC cell lines

Concentrations：

Incubation Time：

Powder Purity:≥99%

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