aladdin 阿拉丁 M409022 6-巯基嘌呤 (6-MP) 50-44-2 10mM in DMSO

中文名：6-巯基嘌呤 (6-MP)

英文名：Mercaptopurine (6-MP)

英文别名：3H-purine-6(7H)-thione

纯度：10mM in DMSO

货号：M409022

包装：1ml

Cas号：50-44-2

存储温度：-80℃储存

产品介绍：

Information

Mercaptopurine (6-MP) Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
In vitro

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

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