aladdin 阿拉丁 L408801 依碳酸氯替泼诺 82034-46-6 10mM in DMSO

中文名：依碳酸氯替泼诺

英文名：Loteprednol etabonate

英文别名：(11β,​17α)​-7-​[(ethoxycarbonyl)​oxy]​-​11-​hydroxy-​3-​oxo-androsta-​1,​4-​diene-​17-​carboxylic acid chloromethyl ester

纯度：10mM in DMSO

货号：L408801

包装：1ml

Cas号：82034-46-6

存储温度：-80℃储存

产品介绍：

Information

Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
In vitro

Loteprednol possesses a metabolically labile function, the 17beta-ester, that is designed to be rapidly deactivated in the systemic circulation. Loteprednol etabonate exhibits a binding affinity which is 4.3 times that of dexamethasone, both compounds having a Hill factor close to 1 whereas PJ90 and PJ91 does not show any affinity to the receptor.

In vivo

Loteprednol etabonate administrated directly into the joint effectively blocks the inflammatory response. Loteprednol etabonate prevents the adverse inflammatory effects of antigen action in a rabbit acute experimental model for arthritis. Loteprednol etabonate (LE) (oral) reaches the upper GI tract effectively, but not the colon, due to absorption and/or decomposition in rats. Loteprednol etabonate (LE) shows a rapid, dose-dependent elimination with a total blood clearance (CLtotal) of higher than 60 ml/min/kg in rats. Loteprednol etabonate absorbes systemically, after topical administration, can be rapidly transformed to the inactive metabolites, and eliminates from the body mainly through the bile and urine.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

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