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  • aladdin 阿拉丁 L408678 盐酸洛哌丁胺 34552-83-5 10mM in DMSO

aladdin 阿拉丁 L408678 盐酸洛哌丁胺 34552-83-5 10mM in DMSO

Loperamide HCl
34552-83-5
463.90 1ml 起订
上海 更新日期:2024-11-29

上海阿拉丁生化科技股份有限公司

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联系人:阿拉丁客服
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邮箱:market@aladdin-e.com

产品详情:

中文名称:
盐酸洛哌丁胺
英文名称:
Loperamide HCl
CAS号:
34552-83-5
品牌:
阿拉丁
产地:
上海
保存条件:
-80℃储存
纯度规格:
10mM in DMSO
产品类别:
药靶配体 药靶配体
分子式:
C29H33ClN2O2·HCl
分子量:
513.5
运输条件:
超低温冰袋运输
产品规格:
1ml
货号:
L408678
是否进口:

中文名:盐酸洛哌丁胺

英文名:Loperamide HCl

英文别名:ADL 2-1294;4-​(4-​chlorophenyl)​-​4-​hydroxy-​N,​N-​dimethyl-​α,​α-​diphenyl-1-​piperidinebutanamide​, hydrochloride (1:1)

纯度:10mM in DMSO

货号:L408678

包装:1ml

Cas号:34552-83-5

存储温度:-80℃储存

产品介绍:

Information

Loperamide HCl (ADL 2-1294) is a selectiveμ-opioid receptoragonist opioid withKiof 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bow
In vitro

Loperamide exhibits potent affinity and selectivity for the cloned micro (Ki = 3 nM) compared with the delta (Ki = 48 nM) and kappa (Ki = 1156 nM) human opioid receptors. Loperamide potently stimulates [35S]guanosine-5\'-O-(3-thio)triphosphate binding with EC50 of 56 nM, and inhibits forskolin-stimulated cAMP accumulation (IC50 = 25 nM) in Chinese hamster ovary cells transfected with the human mu opioid receptor. Loperamide potently inhibits late-phase formalin-induced flinching after intrapaw injection (A50 = 6 mg). Loperamide is a strong inhibitor of CES2, with a K(i) of 1.5 muM, but it only weakly inhibits CES1A1 (IC50 = 0.44 mM). Loperamide reversibly blocks rises in [Ca2+]i evoked by high [K+] in a concentration-dependent manner, with an IC50 of 0.9 mM. Loperamide (0.1-50 mM) produces a concentration-dependent reduction of the peak IBa with an IC50 value of 2.5 mM and, at the highest concentration tested, could fully block IBa in the absence of any other pharmacological agent. Loperamide also attenuates NMDA-evoked currents recorded at a membrane potential of -60 mV, with an IC50 of 73 mM.

In vivo

Loperamide, an opioid agonist unable to cross the blood-brain barrier, inhibits both thermal and mechanical hyperalgesia when s.c. injected, locally over the tibial tumoral mass (7.5-75 mg) or distantly, under the fur of the neck (4 mg/kg) in mice.
Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

查看阿拉丁官网此产品相关对应页面:https://www.aladdin-e.com/zh_cn/L408678.html


ADL 2-1294;4-?(4-?chlorophenyl)?-?4-?hydroxy-?N,?N-?dimethyl-?α,?α-?diphenyl-1-?piperidinebutanamide?, hydrochloride (1:1)

公司简介

上海阿拉丁生化科技股份有限公司是A股上市公司((股票代码:688179),专注于科研试剂的研发、生产和销售,已陆续建立多个工厂和研发中心。作为领军企业,阿拉丁始终坚持质量第一,连续13年被评为“最受欢迎试剂品牌”。 阿拉丁目前常备库存试剂产品品种超过7万种,SKU总数超过46万,产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域,是国内少数化学试剂到生物试剂全面发展的国产试剂品牌,产品同步发布在我们国内外电商平台。

成立日期 (16年)
注册资本 14130.676万人民币
员工人数 500人以上
年营业额 ¥ 1亿以上
经营模式 工厂,试剂
主营行业 生物化工,化学试剂

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