aladdin 阿拉丁 B407765 (2'Z,3'E)-6-溴靛玉红-3'-肟 667463-62-9 10mM in DMSO

中文名：(2'Z,3'E)-6-溴靛玉红-3'-肟

英文名：BIO

英文别名：GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052;2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-

纯度：10mM in DMSO

货号：B407765

包装：1ml

Cas号：667463-62-9

存储温度：-80℃储存

产品介绍：

Information

BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor ofGSK-3withIC50of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAKinhibitor with IC50 of 30 nM forT
In vitro

BIO (6-bromoindirubin-3\'-oxime) is a specific inhibitor of glycogen synthase kinase-3 (GSK-3), with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5. BIO interacts within the ATP binding pocket of these kinases, reduces β-catenin phosphorylation on a GSK-3-specific site in cellular models, closely mimicks Wnt signaling in Xenopus embryos. In human and mouse embryonic stem cells, BIO maintains the undifferentiated phenotype and sustains expression of the pluripotent state-specific transcription factors Oct-3/4, Rex-1 and Nanog. BIO-mediated Wnt activation is functionally reversible, as withdrawal of the compound leads to normal multidifferentiation programs in both human and mouse embryonic stem cells. BIO promotes proliferation in mammalian cardiomyocytes. 6BIO is also a pan-JAK inhibitor, with IC50 values of 0.03, 1.5, 8.0, 0.5 μM for TYK2, JAK1, JAK2 and JAK3. BIO selectively inhibits phosphorylation of STAT3 and induces apoptosis of human melanoma cells.

In vivo

BIO suppresses melanoma tumor growth in a mouse xenograft model.
Cell Data

cell lines：

Concentrations：~10 μM

Incubation Time：12 or 24 h

Powder Purity:≥99%

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