aladdin 阿拉丁 U409233 Ulixertinib (BVD-523) 869886-67-9 10mM in DMSO

中文名：Ulixertinib (BVD-523)

英文名：Ulixertinib (BVD-523)

纯度：Moligand™，≥99%

货号：U413857

Cas号：869886-67-9

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Ulixertinib (BVD-523) Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.

Targets

ERK1 ; ERK2 ; <0.3 nM

In vitro

In an A375 melanoma cell line containing a b-RAFV600E mutation, Ulixertinib reduces the levels of phosphorylated ERK2 (pERK) and of the phosphorylation of the downstream kinase RSK (pRSK) with IC50 of 4.1/0.14 μM, respectively. Ulixertinib also inhibits A375 cell proliferation with IC50 of 180 nM.

Cell Research(from reference)

Cell lines：A375 cells 

Concentrations：~30 μM 

Incubation Time：72 h 

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