aladdin 阿拉丁 O413808 Omaveloxolone (RTA-408) 1474034-05-3 98%

中文名：Omaveloxolone (RTA-408)

英文名：Omaveloxolone (RTA-408)

纯度：Moligand™，≥98%

货号：O413808

Cas号：1474034-05-3

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

Targets

NF-κB ; Nrf2

In vitro

RTA 408 potently increases expression of Nrf2 target genes and reverses IFNγ-mediated suppression of Gclc expression in RAW 264.7 cells. In a panel of eight human tumor cell lines, RTA 408 inhibits growth with an average GI50 value of 260 nM and induces apoptosis. RTA 408 also inhibits NF-κB and activates JNK in tumor cells.

In vivo

In mice with radiation-induced dermatitis, 1.0% RTA 408 markedly reduces epidermal and collagen thickening, prevents dermal necrosis and completely alleviates skin ulcers. In rat skin, RTA 408 activates Nrf2 and induces cytoprotective genes. RTA 408 also mitigates hematopoietic acute radiation syndrome in mice.

Cell Research(from reference)

Cell lines：A375, NCI-H460, A2058, MDA-Mb-231, HCT116, 786-0, A549, and PANC-1 cells 

Concentrations：~1 μM 

Incubation Time：72 hours 

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