aladdin 阿拉丁 O413885 Ochromycinone (STA-21) 111540-00-2 98%

中文名：Ochromycinone (STA-21)

英文名：Ochromycinone (STA-21)

纯度：≥98%

货号：O413885

Cas号：111540-00-2

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Application：

STA-21 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor to study its effects on glioblastoma and primary glioblastoma cells. It has also been used as a STAT3 dimerization inhibitor to study its effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) production in human lung cancer cell line.

Information

Ochromycinone (STA-21) is a selectiveSTAT3inhibitor.

Targets

STAT3

In vitro

In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways.

In vivo

In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3.

Cell Research(from reference)

Cell lines：MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, MCF7, and Caov-3 cells 

Concentrations：20 or 30 μM 

Incubation Time：48 h 

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/O413885.html