产品名称：Recombinant Human LR3 IGF-1 Protein

规格或纯度：ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE&HPLC)

产品介绍：

pH值：6.5-7.5
胰岛素样生长因子-1（IGF-1）是一种分子量为7.6kD的激素，其分子结构与胰岛素类似。IGF-1的主要作用机理是通过与其特异性受体（IGF1R）结合来诱导细胞内的信号传导。IGF-1是AKT信号通路的最有效的激活因子之一，激活AKT信号通路后，刺激细胞生长及增殖，并抑制细胞凋亡。IGF-1 LR3在完整的IGF-1分子的N端添加了13个氨基酸形成83个氨基酸的长链IGF-1，并将IGF-1分子的第3个氨基酸谷氨酸（E）用精氨酸（R）取代，所以称为R3。IGF-1 LR3与未作修饰的IGF-1相比，具有更高的稳定性和生物活性。

生物活性：Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is typically less than 10ng/mL.

纯度：≥95%(SDS-PAGE&HPLC)

氨基酸：40-118 aa

蛋白长度：Full length protein

无载体：Yes

无动物源：Yes

Accession #：P05019.2

预测分子量：9.1 kDa

SDS-PAGE：10.1 kDa, under reducing conditions; 10.1 kDa, under non-reducing conditions.

级别：无动物源, 无载体, 生物活性, ActiBioPure™, 无叠氮钠, 高性能

应用：Active, SDS-PAGE

储存缓冲液：10mM PBS, pH 7.0

复溶：Reconstitute in water to a concentration of 1mg/ml.

储存温度：-20°C储存,避免反复冻融

运输条件：超低温运输

稳定性与储存：Freeze-dried powder can be stored at room temperature for 3 weeks, or frozen at -20℃ for long-term storage. After redissolving it can be refrigerated at 4℃ for at least 2-7 days.

CAS编号和信息：946870-92-4

Accession #：P05019.2

生物活性：Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is typically less than 10ng/mL.

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