aladdin 阿拉丁 H414172 HS-1371 2158197-70-5 98%

中文名：HS-1371

英文名：HS-1371

纯度：≥98%

货号：H414172

Cas号：2158197-70-5

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

HS-1371 HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM. It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.

Targets

RIP3 kinase 20.8 nM

In vitro

HS-1371 shows an inhibitory effect on S227 auto-phosphorylation of RIP3 at the basal level. It displays a complete inhibitory effect on TNF-induced necroptosis signaling, showing no phosphorylation of RIP3 and MLKL in HT-29 cells. Inhibition of RIP3 kinase activity by HS-1371 blocks necrosome complex formation, showing disruption of MLKL recruitment. HS-1371 rescues cells from TNF-induced necroptosis. It rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death.

Cell Research(from reference)

Cell lines：HT-29 cells 

Concentrations：5 μM 

Incubation Time：2 h 

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