aladdin 阿拉丁 P413931 PF-CBP1盐酸 2070014-93-4 96%

中文名：PF-CBP1盐酸

英文名：PF-CBP1 HCl

纯度：≥96%

货号：P413931

Cas号：2070014-93-4

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

PF-CBP1 HCl PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP) .It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.

Targets

CREBBP (Cell-free assay); p300/CBP (Cell-free assay) 125nM; 363nM

In vitro

PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson\'s disease.It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high.

Cell Research(from reference)

Cell lines：mouse J774 macrophage-like cell line 

Concentrations：0.1-10\xa0μM 

Incubation Time：30min 

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