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网站主页 化工产品目录 生物化工 抑制剂 PI3K/Akt/mTOR抑制剂(PI3K/Akt/mTOR) Akt 抑制剂 MK-2206 2HCl MK-2206
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MK-2206

广东 更新日期:2015-04-01

珠海市活力达生物科技有限公司

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中文名称:
MK-2206
CAS号:
1032350-13-2

MK-2206, a highly selective non-ATP competitive allosteric Akti, has nM IC50 and broad preclinical antitumor activity. [1]
MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. 1 hr treatment of 1 μM MK-2206 abolished Akt phosphorylation in U87MG cells. MK-2206 treatment abolished IR-induced Akt phosphorylation. Moreover, treatment with MK-2206 also increased the radiosensitivity of U87MG cells. [1]
MK-2206 is generally well tolerated at doses up to 60 mg QOD with plasma concentrations that portend activity in preclinical models. PK/PD data suggest a substantial and maintained target inhibition should at 60 mg. [2]


成立日期 (10年)
注册资本 100万人民币
员工人数 1-10人
年营业额 ¥ 100万以内
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